ABSTRACT
BACKGROUND: Squamous cell carcinoma of the oral cavity is a highly invasive neoplasm that spreads locally and metastasizes to regional lymph nodes. This process involves multiple proteolytic enzymes including matrilysin (MMP-7) and membrane type I-matrix metalloproteinase (MT1-MMP). This study was designed to explore the association between MMP-7 and MT1-MMP in the invasiveness and prognosis of oral squamous cell carcinoma (OSCC). METHODS: About 4-microM, formalin-fixed, paraffin-embedded tissue sections from 69 patients with OSCC were immunohistochemically studied using specific antibodies against MMP-7 and MT1-MMP proteins. Immunostaining was semiquantitatively scored, and results were correlated with histologic and clinical variables including clinical behavior and survival. RESULTS: MMP-7 was observed only in cancer cells, and MT1-MMP in both tumoral tissue and stroma. MMP-7 expression was significantly correlated with lymph node metastasis (P = 0.03; RR = 3.2). MT1-MMP showed a significant association with TIMP-2 (in N+ cases) and p53 expression (P = 0.01). MMP-7 and MT1-MMP displayed a survival relevance, and in multivariate analysis they were independent prognostic indicators, particularly in neck node-positive cases.
Subject(s)
Carcinoma, Squamous Cell/pathology , Matrix Metalloproteinase 14/analysis , Matrix Metalloproteinase 7/analysis , Mouth Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/enzymology , Carcinoma, Squamous Cell/secondary , Cohort Studies , Female , Forecasting , Humans , Lymphatic Metastasis/pathology , Male , Matrix Metalloproteinase 2/analysis , Matrix Metalloproteinase 9/analysis , Middle Aged , Mouth Neoplasms/enzymology , Neoplasm Invasiveness , Neoplasm Staging , Prognosis , Retrospective Studies , Survival Rate , Tissue Inhibitor of Metalloproteinase-1/analysis , Tissue Inhibitor of Metalloproteinase-2/analysis , Tumor Suppressor Protein p53/analysisABSTRACT
Presentamos el caso de un varón de 65 años con un angiomioma del espacio retrofaríngeo. El angiomioma es un tumor que se origina en el músculo liso de la pared de los vasos sanguíneos. Es un tipo de tumor relativamente raro en cabeza y cuello, especialmente en localizaciones profundas. Este es el segundo caso descrito de angiomioma en el espacio retrofaríngeo. Aunque los estudios de imagen y la punción-aspiración con aguja fina (PAAF) apuntan hacia un tumor de origen vascular, el diagnóstico de esta lesión se realiza sólo mediante biopsia excisional y tinción con vimentina, desmina, actina o miosina. El tratamiento consiste en resección quirúrgica, y la recurrencia del tumor tras ello es excepcional (AU)
We report the case of a 65-year-old male patient with an angiomyoma of the retropharyngeal space. Angiomyoma is a tumour that arises from the smooth muscle in the wall of blood vessels. It is a relatively rare tumour of the head and neck, mostly in deep locations. This one is the second reported angiomyoma of the retropharyngeal space. Although image examinations and fine needle aspiration (FNA) did point to a vascular tumour, the diagnosis of this lesion is made by on excisional biopsy and histological staining with vimentin, desmin, actin or myosin. The treatment is excision of the tumour and recurrence is exceptional (AU)
