Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?

BACKGROUND: To assess the impact of the lung cancer screening protocol recommended by the European Society of Thoracic Imaging (ESTI) on nodule diameter, volume, and density throughout different computed tomography (CT) scanners. METHODS: An anthropomorphic chest phantom containing fourteen different-sized (range 3-12 mm) and CT-attenuated (100 HU, -630 HU and -800 HU, termed as solid, GG1 and GG2) pulmonary nodules was imaged on five CT scanners with institute-specific standard protocols (PS) and the lung cancer screening protocol recommended by ESTI (ESTI protocol, PE). Images were reconstructed with filtered back projection (FBP) and iterative reconstruction (REC). Image noise, nodule density and size (diameter/volume) were measured. Absolute percentage errors (APEs) of measurements were calculated. RESULTS: Using PE, dosage variance between different scanners tended to decrease compared to PS, and the mean differences were statistically insignificant (p = 0.48). PS and PE(REC) showed significantly less image noise than PE(FBP) (p < 0.001). The smallest size measurement errors were noted with volumetric measurements in PE(REC) and highest with diametric measurements in PE(FBP). Volume performed better than diameter measurements in solid and GG1 nodules (p < 0.001). However, in GG2 nodules, this could not be observed (p = 0.20). Regarding nodule density, REC values were more consistent throughout different scanners and protocols. CONCLUSION: Considering radiation dose, image noise, nodule size, and density measurements, we fully endorse the ESTI screening protocol including the use of REC. For size measurements, volume should be preferred over diameter.

Fluoroscopy-guided vs. navigated iliosacral screw placement with intraoperative 3D scan or postoperative CT control: Impact of the clinical workflow on patients' radiation exposure: Radiation exposure of different workflows for iliosacral screw placement.

INTRODUCTION: To guide iliosacral screws (ISS) and verify safe placement different techniques, e.g. Fluoroscopy-guided (FSG) or 3D navigation are known. However, higher radiation exposure for the conventional technique is a concern. It was the aim of this experimental study to evaluate radiation exposure for three clinical workflows. METHODS: An anthropomorphic, cross sectional dosimetry phantom was equipped with metal oxide semiconductor field effect transistors to measure organ specific radiation exposure. The effective dose was calculated. Radiation exposure was measured for FSG placement of 2 transverse ISS based on clinical experience regarding fluoroscopy time (240s). Additional measurements were conducted to calculate the effective dose for an intraoperative 3D scan as used for navigated ISS (high-quality 3D), for intraoperative verification of proper guide wire placement (standard-quality 3D) and for postoperative CT, using three different protocols. The following workflows were compared: FSG including postoperative CT (FSG-CT, including 3 different protocols) vs. FSG with intraoperative 3D scan in standard quality (FSG-3D) vs. navigation including two intraoperative 3D scan for navigated ISS (NAV-3D). RESULTS: The effective dose for FSG-CT ranged from 4.41 mSv to 5.27 mSv. FSG-3D resulted in a total of 4.93 mSv. For NAV-3D, the effective dose was the lowest (3.00 mSv). The effective dose of a high-quality 3D scan required for navigation was 1.94 mSv, compared to 1.06 mSv for a standard-quality 3D scan as used for control. CONCLUSIONS: Intraoperative 3D scanning may be recommended, either combined with prior FSG ISS placement or following 3D navigation without increasing radiation exposure compared with alternative workflows with postoperative CT control.

The impact of the fluoroscopic view on radiation exposure in pelvic surgery: organ involvement, effective dose and the misleading concept of only measuring fluoroscopy time or the dose area product.

INTRODUCTION: Minimally invasive fluoroscopy-guided screw fixation is an established technique to stabilize fractures of the posterior pelvic ring in orthopaedic surgery. However, safe placement of the screws may be associated with prolonged intervention time and extensive fluoroscopy is a concern. In the current literature, the dose area product (DAP) and fluoroscopy time are often used to describe radiation exposure of the patient. It was the aim of the study to compare DAP to organ doses and the effective dose for four standard views commonly used in pelvic surgery. METHODS: An anthropomorphic cross-sectional dosimetry phantom, representing the body of a male human (173 cm/73 kg), was equipped with metal-oxide-semiconductor field-effect transistors (MOSFET) in different organ locations to measure radiation exposure. Anteroposterior (APV), lateral (LV), outlet (OLV) and inlet (ILV) of the phantom were obtained with a mobile C-arm, and effective dose and organ doses were calculated. DAP was measured in the built-in ionisation chamber beyond the collimator of the C-arm. The measurements were repeated with a fat layer to simulate an obese patient. RESULTS: Overall, the highest organ dose was measured in the stomach for ILV (0.918 mSv/min). Effective dose for ILV showed the highest values by far (1.85 mSv/min) and the lowest for LV (0.46 mSv/min). The DAP pattern was completely different to the effective dose with similar values for LV and ILV (12.2 and 12.3 µGy·m2/s). Adding a fat layer had no major effect on the measurements. CONCLUSION: The exposure to radiation varies considerably between different orthopaedic standard views of the pelvis. About the fourfold amount of the effective dose was measured for ILV compared to LV. DAP and irradiation time do not respect either the body region in the field of radiation or the radiosensitivity of the affected organs. Thus, they do not allow a reliable interpretation of the radiation burden the patient is exposed to.