ABSTRACT
In contrast to the dog in which pancreas dysfunction is usually clinically diagnosed and frequently described in the literature, this diseases is mostly discovered at necropsy and rarely reported in cats. The objective of this review is to show increased attention to the occurrence of pancreatic diseases in cat.
Subject(s)
Cat Diseases/pathology , Pancreatic Diseases/veterinary , Animals , Cat Diseases/diagnosis , Cats , Diagnosis, Differential , Pancreatic Diseases/diagnosis , Pancreatic Diseases/pathology , Pancreatitis/diagnosis , Pancreatitis/pathology , Pancreatitis/veterinaryABSTRACT
Morphological and cytochemical characteristics of both bone marrow and peripheral blood cells as well as an appreciation of the course of the disease, were found to be important in making the correct diagnosis in a dog with acute myeloblastic leukaemia similar to the M-2 type (FAB classification) of man. Busulfan treatment resulted in only a limited effect, mainly consisting in a reduction of the number of nucleated cells in the peripheral blood. Even under busulfan treatment, however, the relative blast count in marrow and peripheral blood increased, indicating that most blast cells were not susceptible to the action of busulfan. The total survival time of the dog was 94 days, including 24 days from hospitalization and diagnosis until euthanasia in a moribund state. Based on the assessment of morphological abnormalities in leukaemic cells and of mitotic indices in bone marrow smears, it is tentatively concluded that the acute myeloblastic leukaemia in this dog arose in the pluripotent haematopoietic stem cell compartment giving rise to the formation of erythrocytes, eosinophils, neutrophils and monocytes as well as megakaryocytes and that the proliferation rate of cells of the myeloblastic clone was decreased, although an increase in the size of the potentially dividing compartment might have occurred.
Subject(s)
Dog Diseases/diagnosis , Leukemia, Myeloid, Acute/veterinary , Animals , Bone Marrow/pathology , Cell Division , Cell Line , Dog Diseases/pathology , Dogs , Erythrocytes/cytology , Female , Granulocytes/cytology , Leukemia, Myeloid, Acute/diagnosis , Leukemia, Myeloid, Acute/pathology , Reference ValuesSubject(s)
Cat Diseases/diagnosis , Opisthorchiasis/veterinary , Animals , Cats , Female , Liver/parasitology , Opisthorchiasis/diagnosis , Opisthorchis , Pancreas/parasitology , SwitzerlandABSTRACT
The pancreas of dogs with the clinical syndrome of chronic pancreatic insufficiency was examined macroscopically, by light- and electron microscopy and immunohistochemically. The pancreatic tissue was reduced in volume, the lobular architecture was disturbed and the ductal system prominent. Many acini were shrunken and contained cells with pyknotic nuclei. The islets of Langerhans were highly irregular, often difficult to identify. Many B cells occurred isolated within the exocrine tissue. Ultrastructurally, changes in the acinar cells included alterations in the chromatin pattern and dilatation of the cisternae of the rough endoplasmic reticulum. In endocrine cells nuclear deformations, chromatin condensation and progressive loss of secretory granules were seen, accompanied by vacuolization of the cytoplasm. The changes included all endocrine cell types. This complex of pancreatic lesions is considered to be of degenerative origin. The aetiology of the disease is unknown.
