Collagenase Clostridium Histolyticum for Dupuytren's Contracture: Comparing Single and Concurrent Injections.

BACKGROUND: The U.S. Food and Drug Administration approved collagenase clostridium histolyticum for treatment of Dupuytren's contracture in 2010, and for the concurrent treatment of up to two cords in 2014. Although outcomes and adverse events have been well described for single injections, comparative data on concurrent injections are lacking. METHODS: The authors reviewed 121 concurrent collagenase clostridium histolyticum injections and compared these with 177 single injections over 8 years. All injections were performed by a single surgeon, our senior author (D.F.). A retrospective cohort model was used to compare clinical outcomes and adverse events (i.e., skin tears, spontaneous cord rupture, tendon rupture, lymphadenopathy, blood blisters, and ecchymosis) between groups. RESULTS: There were no statistical differences between groups in clinical success rate or change in contracture per joint. The rate of skin tears per joint in concurrent injections (22.3 percent) was not statistically different from that of single injections (18.6 percent; p = 0.46), and was consistent with previously reported rates. The rate of skin tears did not change significantly over time in either group. Concurrent injection did not influence the incidence of skin tears in a dose-dependent manner (relative risk, 1.20). Patients receiving concurrent injections experienced a higher rate of lymphadenopathy compared with those receiving single injections (p = 0.001). CONCLUSIONS: Concurrent collagenase clostridium histolyticum injections for Dupuytren's contracture have a similar safety profile and treatment efficacy when compared to single injections. The authors did not find a dose-dependent relationship between skin tears and collagenase clostridium histolyticum injected. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.

Diagnosis and localisation of flexor tendon injuries by surgeon-performed ultrasound: A cadaveric study.

BACKGROUND: Flexor tendon injuries are common problems faced by hand surgeons. To minimise the surgical trauma associated with localisation and retrieval of the proximal tendon end, we investigated the use of surgeon-performed ultrasound in the evaluation of injured flexor tendons in a cadaver model. Our goal was to use surgeon-performed ultrasound: (1) to correctly diagnose flexor tendon injuries and (2) to correctly localise the proximal tendon ends within 1cm. METHODS: Flexor tendon injuries with varying degrees of retraction were randomly created in individual digits of cadaver upper extremities, with a number of tendons left uninjured. A surgeon, blinded to the injury status of each digit, imaged each tendon by ultrasound. Predicted injury status of each tendon and localisation of the proximal stump was recorded. A total of 81 tendons were studied. FINDINGS: Correct diagnosis of flexor tendon injury was made in 78 of 81 tendons (96.2% success). Correct localisation of the proximal tendon stump was made in 39 of 50 lacerated tendons (78% success). Small finger injuries were most difficult to assess (66.7% success). With the small finger excluded from our analysis, the localisation success rate increased to 86.8%. The average time taken to image each digit was just under 2.5min. CONCLUSIONS: Surgeon-performed ultrasound evaluation of the hand is a reliable means to diagnose flexor tendon injuries and to accurately localise the proximal tendon ends. This imaging modality may limit the need for extensive surgical exploration during flexor tendon repair. We do not recommend using this technique to image flexor tendon injuries of the small finger at this time.

High-pressure hand injection injuries caused by dry cleaning solvents: case reports, review of the literature, and treatment guidelines.

A previously unreported subset of high-pressure injection injuries, namely those involving solvents used in the garment dry cleaning industry, is presented. Dry cleaning solutions contain isoparaffinic hydrocarbons, methoxypropanol, and dichlorofluoroethane. Although these solvents have limited potential for systemic toxicity, severe local toxicity causing tissue necrosis often results in loss of the injured digit. Proper treatment includes prompt surgical exploration, careful débridement and irrigation, intravenous antibiotics, and in selected cases, high-dose systemic corticosteroids.