Porcelain veneer restorations: a clinician's opinion about a disturbing trend.

The conservative nature of the porcelain veneer technique introduced in 1982 is becoming less evident today. Even though dentin bonding materials are improving and emerging clinical research is encouraging, intact enamel provides the most reliable substrate for etched porcelain veneer restorations. Preparations can be designed with supragingival finish lines and, with the CLE, can be virtually invisible. Recent trends indicate that some practitioners dismiss the importance of enamel. An alarming number of patients are presenting with partial or complete debonding of porcelain veneer restorations placed for elective esthetics. When such failures do occur, the need for corrective measures is no longer discretionary. For many clinical conditions, porcelain veneer restorations offer dentists and their patients an outstanding, conservative alternative to traditional crowns. Veneers should always be minimally invasive. Dentists should not yield co pressures generated by well-meaning dental technicians and colleagues who disregard the importance of enamel bonding. They should also consider treatment options that preserve natural tooth structure, promote a healthy dentition, and reduce the need for future re-treatment. Sometimes the appropriate option is no treatment. Few dentists would want to have their own teeth aggressively prepared if a more conservative approach were feasible. Their patients certainly deserve the same consideration.

Developing effective treatments for posttraumatic disorders among people with severe mental illness.

OBJECTIVE: The purpose of the study was to examine strategies for developing effective interventions for clients who have both serious mental illness and posttraumatic symptoms. METHODS: The authors conducted searches for articles published between 1970 and 2000, using MEDLINE, PsycLIT, and PILOTS. They assessed current practices, interviewed consumers and providers, and examined published and unpublished documents from consumer groups and state mental health authorities. RESULTS AND CONCLUSIONS: Exposure to trauma, particularly violent victimization, is endemic among clients with severe mental illness. Multiple psychiatric and behavioral problems are associated with trauma, but posttraumatic stress disorder (PTSD) is the most common and best-defined consequence of trauma. Mental health consumers and providers have expressed concerns about several trauma-related issues, including possible underdiagnosis of PTSD, misdiagnosis of other psychiatric disorders among trauma survivors, incidents of retraumatization in the mental health treatment system, and inadequate treatment for trauma-related disorders. Despite consensus that trauma and PTSD symptoms should be routinely evaluated, valid assessment techniques are not generally used by mental health care providers. PTSD is often untreated among clients with serious mental illness, or it is treated with untested interventions. It is important that policy makers, service system administrators, and providers recognize the prevalence and impact of trauma in the lives of people with severe mental illness. The development of effective treatments for this population requires a rational, orderly process, beginning with the testing of theoretically grounded interventions in controlled clinical trials.

Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice.

Cocaine's ability to interact with sigma receptors suggests that these proteins mediate some of its behavioral effects. Therefore, three novel sigma receptor ligands with antagonist activity were evaluated in Swiss Webster mice: BD1018 (3S-1-[2-(3,4-dichlorophenyl)ethyl]-1,4-diazabicyclo[4.3.0]nonane), BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), and LR132 (1R,2S-(+)-cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamine). Competition binding assays demonstrated that all three compounds have high affinities for sigma1 receptors. The three compounds vary in their affinities for sigma2 receptors and exhibit negligible affinities for dopamine, opioid, GABA(A) and NMDA receptors. In behavioral studies, pre-treatment of mice with BD1018, BD1063, or LR132 significantly attenuated cocaine-induced convulsions and lethality. Moreover, post-treatment with LR132 prevented cocaine-induced lethality in a significant proportion of animals. In contrast to the protection provided by the putative antagonists, the well-characterized sigma receptor agonist di-o-tolylguanidine (DTG) and the novel sigma receptor agonist BD1031 (3R-1-[2-(3,4-dichlorophenyl)ethyl]-1,4-diazabicyclo[4.3.0]nonane) each worsened the behavioral toxicity of cocaine. At doses where alone, they produced no significant effects on locomotion, BD1018, BD1063 and LR132 significantly attenuated the locomotor stimulatory effects of cocaine. To further validate the hypothesis that the anti-cocaine effects of the novel ligands involved antagonism of sigma receptors, an antisense oligodeoxynucleotide against sigma1 receptors was also shown to significantly attenuate the convulsive and locomotor stimulatory effects of cocaine. Together, the data suggests that functional antagonism of sigma receptors is capable of attenuating a number of cocaine-induced behaviors.

Evaluation and treatment of recurrent instability after anterior cruciate ligament reconstruction.

Revision ACL surgery has become increasingly common. Successful revision surgery requires a thorough preoperative evaluation, including a detailed history and a physical and radiographic examination. Preoperative planning is imperative for a successful outcome, as it limits the potential for repeating the errors that led to the failure of the primary procedure. This begins with a determination of the mechanism of failure. Often, a primary as well as a secondary cause of failure can be identified. Determination of the etiology of failure is the first step in a carefully constructed treatment plan, which includes the type of revision and skin incision, graft and hardware removal, tunnel placement, graft selection and fixation, and the rehabilitation protocol. The preoperative plan should have enough flexibility to accommodate unanticipated findings in the operating room. Finally, the importance of counseling the patient preoperatively regarding potential results must be emphasized. Given the complexity of revision ACL reconstruction, the patient's expectations must be adjusted to realistically match the potential for success. The goal of successful revision surgery may be only to return the patient to activities of daily living or work, especially if there is evidence of degenerative joint disease. With proper planning and attention to detail, revision ACL surgery can provide a satisfying solution to difficult cases of knee instability.

Design of Department of Veterans Affairs Cooperative Study no. 420: group treatment of posttraumatic stress disorder.

Posttraumatic stress disorder (PTSD) is a significant problem for a large number of veterans who receive treatment from the Department of Veterans Affairs (VA) health-care system. VA Cooperative Study 420 is a randomized clinical trial of group psychotherapy for treating PTSD among veterans who sought VA care. Participants at ten sites were randomly assigned to receive one of the two treatments: active treatment that embedded exposure therapy in a group context or comparison treatment that avoided trauma focus and instead addressed current interpersonal problems. Treatment was delivered weekly to groups of six participants for 30 weeks, followed by five monthly booster sessions. Follow-up assessments were conducted at the end of treatment (7 months) and the end of boosters (12 months) for all participants. Long-term follow-up data were collected for a subset of participants at 18 and 24 months. The primary outcome is PTSD severity; other symptoms, functional status, quality of life, physical health, and service utilization also were assessed. Data analysis will account for the clustering introduced by the group nature of the intervention. The pivotal comparison was at the end of treatment. Analyses of subsequent outcomes will concentrate on the question of the durability of effects. The study provides an example of how to address the unique challenges posed by multisite trials of group psychotherapy through attention to methodological and statistical issues. This article discusses these challenges and describes the design and methods of the study. Control Clin Trials 2001;22:74-88

Using AMSA and P-ASA nerve blocks for esthetic restorative dentistry.

Esthetic restorative dentistry procedures represent an increasing segment of the services provided by the general practitioner. One important assessment criterion for a successful anterior esthetic restoration is how well it harmonizes with the lips to create a pleasing smile line. Unfortunately, traditional local anesthetic techniques interfere with this assessment by distorting the lips and face during anesthesia. The anterior, middle superior alveolar block and the palatal approach anterior superior alveolar block injections represent two recently defined techniques to anesthetize maxillary teeth effectively without numbness of the face, lips, or muscles of expression. Although safety and efficacy studies are only beginning to emerge, these injections appear to be useful additions to local anesthetic techniques, especially when anterior esthetic restorative procedures are being performed.

An in vitro study of needle force penetration comparing a standard linear insertion to the new bidirectional rotation insertion technique.

OBJECTIVE: The purpose of this study was to determine the effect of a bidirectional rotation insertion technique on the force necessary to puncture and advance a needle through a tissuelike substance. METHOD AND MATERIALS: Two in vitro penetration test models were constructed using different tissuelike substances of different densities. Each tissuelike substance was tested with 30-gauge, 27-gauge, and 25-gauge needles of two brands commonly used in dentistry. The needles were placed to a standardized depth of 0.5 inch (1.27 cm) at a standardized rate of insertion. A customized dental surveyor allowed controlled forces to be applied. A linear insertion technique and a newly described bidirectional rotation insertion technique were tested. The force of puncture and penetration drag was recorded with an electronic digital scale. A total of 400 needle insertions were performed. RESULTS: A multivariate analysis of technique, material, needle gauge, and needle brand revealed the data to be statistically significant, demonstrating no overlap. The post-hoc analysis of between-subject effects found that the needle insertion technique accounted for the most powerful effect in reducing force penetration. The bidirectional insertion technique had the greatest influence on reducing the force penetration irrespective of material, needle gauge, or needle brand tested in this study. CONCLUSION: The bidirectional rotation insertion technique required two to three times less force than did a standard linear insertion technique. A continuous rotation in a single direction would be expected to produce similar results. Needle gauge and needle design have a smaller effect on reducing force penetration than did the technique used during insertion. The in vitro model used in this study represents a reliable dynamic testing system that can be used for future evaluation of needles.

Psychophysiological reactivity in female sexual abuse survivors.

This study examined psychophysiological reactivity in 37 female childhood sexual abuse (CSA) survivors. After assessment of posttraumatic stress disorder (PTSD), psychiatric comorbidity, and trauma history, we conducted a psychophysiological assessment of forehead muscle tension, electrodermal activity, and heart rate during a mental arithmetic task and4 script-driven imagery tasks (neutral, consensual sex, pleasant, and trauma). PTSD symptom severity correlated positively with psychophysiologic changes and negative emotions during the trauma imagery task. During mental arithmetic, PTSD symptom severity correlated negatively with autonomic changes and positively with negative emotions. These results extend earlier PTSD research showing trauma-specific increased psychophysiological reactivity related to CSA in women with PTSD. They further suggest a negative association between PTSD severity and autonomic reactions to mental arithmetic.

Graft options for ACL reconstruction.

Once the decision for anterior cruciate ligament (ACL) reconstruction has been made, the orthopedist has to decide which graft substitute will best restore normal anterior knee stability. This article will present an overview of graft options as well as fixation options most commonly used in ACL reconstructions.

PTSD and utilization of medical treatment services among male Vietnam veterans.

This study investigated the effect of posttraumatic stress disorder (PTSD) on help-seeking for physical problems. Merging two large data sets resulted in a sample of 1773 male Vietnam veterans from white, black, Hispanic, Native Hawaiian, and Japanese American ethnic groups. Predictors of utilization included PTSD, other axis I disorders, and substance abuse. In analyses that adjusted only for age, PTSD was related to greater utilization of recent and lifetime VA medical services, and with recent inpatient care from all sources. Further analysis showed that the increased utilization associated with PTSD was not merely due to the high comorbidity between PTSD and other axis I disorders. The uniqueness of the association between PTSD and medical utilization is discussed in terms of somatization and physical illness.

What might the psychobiology of posttraumatic stress disorder teach us about future approaches to pharmacotherapy?

This review considers future directions for developing effective drugs for posttraumatic stress disorder (PTSD). At present, we have embarked upon an empirical approach in which pharmacologic research consists of clinical trials with agents, such as antidepressants, anxiolytics, and anticonvulsants, initially developed for different purposes. The approach taken here is theoretical rather than empirical, starting with what is known about the unique pathophysiology of PTSD and then predicting the types of pharmacologic agents that might prove effective in the future. Such classes of compounds include corticotropin-releasing factor antagonists, neuropeptide Y enhancers, antiadrenergic compounds, drugs to down-regulate glucocorticoid receptors, more specific serotonergic agents, agents normalizing opioid function, substance P antagonists, N-methyl-D-aspartate facilitators, and antikindling/antisensitization anticonvulsants.

Predictors and outcomes of posttraumatic stress disorder in World War II veterans exposed to mustard gas.

Current posttraumatic stress disorder (PTSD) associated with participation in secret military tests of mustard gas during World War II was assessed in 363 male military veterans who were randomly sampled from a registry developed by the Department of Veterans Affairs. Current prevalence was 32% for full PTSD and 10% for partial PTSD. Prevalence of PTSD varied as a function of risk and protective factors, including volunteering, physical symptoms during the tests, and prohibited disclosure. Prediction of partial PTSD was weaker than prediction of full PTSD. Veterans with full PTSD reported poorer physical health, a higher likelihood of several chronic illnesses and health-related disability, greater functional impairment, and higher likelihood of health care use than those with no PTSD. Veterans with partial PTSD also had poorer outcomes than did veterans with no PTSD in a subset of these domains. There is discussion of the traumatic elements of experimental mustard gas exposure, vulnerability to PTSD, and the relevance of these findings to understanding the broad range of outcomes associated with PTSD.

In vitro study of needle deflection: a linear insertion technique versus a bidirectional rotation insertion technique.

OBJECTIVE: Deflection of dental needles during tissue penetration has been associated with a failure to achieve successful anesthesia. The purpose of this study was to determine whether needle deflection in a tissuelike substance could be minimized through the use of a bidirectional rotation insertion technique. METHOD AND MATERIALS: Three in vitro deflection test models were constructed, each incorporating a different tissuelike substance of a different density. Each substance was tested with 3 different needle sizes (30-guage, 27-gauge, and 25-gauge). A customized dental surveyor allowed for standardized needle insertions to a standardized depth of 20 mm. Two different insertion techniques, a linear insertion technique and a newly described bidirectional rotation insertion technique, were tested. Radiographic analysis was performed after each insertion. RESULTS: The bidirectional rotation insertion technique described was consistently more effective in minimizing needle shaft deflection for 30-, 27-, and 25-gauge needles. The differences were statistically significant. Each of the different tissuelike substances consistently demonstrated this reduction in needle deflection. CONCLUSION: The factor that most greatly affects the path taken by a needle through a tissuelike substance is the force vectors that act on the needle's beveled surface. The use of a bidirectional rotation insertion technique minimized needle deflection, resulting in a straighter tracking path for 30-, 27-, and 25-gauge dental needles, in 3 different tissuelike substances tested in this study.

New advances in local anesthesia.

In dentistry, local pain management is a critical component of patient care. When efforts to achieve local anesthesia are unsuccessful, the resulting stress for both the patient and practitioner can be significant. This Forum has reviewed new technologies that are reported to increase the probability of a favorable outcome with local anesthesia. Like all new techniques, devices, and drugs, there is a learning curve that must be mastered. However, the potential benefits of the new devices and techniques available in local anesthesia broaden the practitioners' choices. There may not yet be a "magic bullet" in local anesthesia, but the advances reviewed here hold great promise. Our participants seem to agree that predictable local anesthesia will always require a thorough understanding of the broad range of devices, techniques, and drugs available and a commitment by the dentists to use them wisely.