1.
Cytogenet Cell Genet
; 92(3-4): 300-3, 2001.
Article
in English
| MEDLINE
| ID: mdl-11435703
ABSTRACT
Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8.
Subject(s)
Carrier Proteins/genetics , Chromosomes, Human, Pair 4/genetics , Exons/genetics , Introns/genetics , Membrane Glycoproteins/genetics , Physical Chromosome Mapping , Animals , Base Sequence , Contig Mapping , Expressed Sequence Tags , Gene Expression Profiling , Humans , Internet , Lod Score , Mice , RNA, Messenger/analysis , RNA, Messenger/genetics , Radiation Hybrid Mapping , Sequence Homology
2.
Ann Genet
; 43(2): 109-10, 2000.
Article
in English
| MEDLINE
| ID: mdl-10998454
