ABSTRACT
A method has been developed for the simultaneous gas chromatographic determination of propranolol or metoprolol and butyrophenones butyrophenones in human plasma in vitro. The drugs were extracted from plasma by solid-phase extraction. Calibration graphs were linear in the 50-300-ng/mL range. The recovery of the compounds was 80-90%. The sensitivity of the method was adequate for the determination of the drugs at toxic concentrations and at therapeutic levels. It is a simple, rapid, and reproducible method for the simultaneous determination of propranolol or metoprolol and some butyrophenones. The minimum detectable concentration was 50 ng/mL with a flame ionization detector and 10 ng/mL with a mass spectrometer detector.
Subject(s)
Butyrophenones/blood , Metoprolol/blood , Propranolol/blood , Gas Chromatography-Mass Spectrometry , Humans , Indicators and ReagentsABSTRACT
This report describes a sensitive GC and HRGC-MS procedure for the simultaneous determination of Quinidine and some bytyrophenone drugs in human plasma. The quantitative response is linear from 50-250 ng/ml using Pipamperone as international standard. It is suitable for clinical analysis at therapeutic levels.
Subject(s)
Butyrophenones/blood , Quinidine/blood , Gas Chromatography-Mass Spectrometry , Humans , Indicators and Reagents , Reference Standards , SolutionsABSTRACT
Using a simple, highly sensitive technique, the rate of pollution due to enflurane in an operating theatre with two beds and two respirators but without an air exchange system has been measured. After much debate and after seven serious cases of viral hepatitis among medical staff, the facility was closed because it was judged to be unusable and because the surgical department using it was moved elsewhere.