ABSTRACT
BACKGROUND AND OBJECTIVES: Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recommendations for documentation in regional anesthesia. METHODS: Following the formation of the executive committee and a directed literature review, a long list of potential documentation components was created. A modified Delphi process was then employed to achieve consensus amongst a group of international experts in regional anesthesia. This consisted of 2 rounds of anonymous electronic voting and a final virtual round table discussion with live polling on items not yet excluded or accepted from previous rounds. Progression or exclusion of potential components through the rounds was based on the achievement of strong consensus. Strong consensus was defined as ≥75% agreement and weak consensus as 50%-74% agreement. RESULTS: Seventy-seven collaborators participated in both rounds 1 and 2, while 50 collaborators took part in round 3. In total, experts voted on 83 items and achieved a strong consensus on 51 items, weak consensus on 3 and rejected 29. CONCLUSION: By means of a modified Delphi process, we have established expert consensus on documentation in regional anesthesia.
Subject(s)
Anesthesia, Conduction , Consensus , Delphi Technique , Documentation , HumansABSTRACT
BACKGROUND AND OBJECTIVES: There is little knowledge of the pharmacokinetics of local anesthetics and adjunctive analgesics after paravertebral blockade. We evaluated the pharmacokinetics of low-dose levobupivacaine, fentanyl, and clonidine after paravertebral analgesia for breast surgery. METHODS: Thirty-eight patients receiving paravertebral analgesia for breast surgery received a 19-mL paravertebral bolus of levobupivacaine 0.25% combined with a 1-mL volume of saline (group L, 13 patients), fentanyl 50 microg (group LF, 13 patients), or clonidine 150 microg (group LC, 12 patients) followed 1 hour later by infusion of levobupivacaine 0.1% (L), levobupivacaine 0.05% with fentany l 4 microg/mL (LF), or levobupivacaine 0.05% with clonidine 3 microg/mL (LC), respectively. Plasma concentrations of study drugs were determined at intervals up to 24 hours after bolus injection. RESULTS: There was rapid absorption of levobupivacaine after bolus with mean (standard deviation) maximum plasma concentration (Cpmax) of 0.51(0.24) microg/mL in a median time to maximum concentration tCpmax of 15 minutes. Mean Cpmax fentanyl and clonidine after bolus were 0.62 (0.37) and 0.79 (0.23) ng/mL, in a median tCpmax of 15 and 22.5 minutes, respectively. Mean Cpmax levobupivacaine after infusion was 0.47 (0.41) microg/mL in a median tCpmax of 24 hours. There was progressive accumulation of fentanyl and clonidine at 24 hours with a mean Cpmax of 0.72 (0.33) and 1.74 (0.70) ng/mL, respectively. CONCLUSIONS: After paravertebral bolus and infusion administration, Cpmax levobupivacaine was within the safe range. Cpmax fentanyl and clonidine were less than the effective levels after IV administration, suggesting that their analgesic effect may be partly attributed to a peripheral mechanism of action.
Subject(s)
Analgesia , Anesthetics, Local/pharmacokinetics , Clonidine/pharmacokinetics , Fentanyl/pharmacokinetics , Adult , Anesthetics, Local/blood , Breast Neoplasms/surgery , Bupivacaine/analogs & derivatives , Bupivacaine/blood , Bupivacaine/pharmacokinetics , Clonidine/blood , Drug Administration Routes , Female , Fentanyl/blood , Humans , Levobupivacaine , Mass Spectrometry , Middle Aged , Pain, Postoperative/prevention & control , Thoracic Vertebrae/innervationABSTRACT
Regional anesthesia has many advantages, which include low cost, ease of administration, and avoidance of risks associated with general anesthesia. Injection of local anesthetic via a needle as part of a regional anesthetic technique can be a stressful experience. The goal is to produce a relaxed patient who is comfortable and cooperative throughout the duration of surgery. The topics of regional anesthetic techniques, drug combinations, and adjunct measures such as sedation have been described extensively in the literature. The issue of patient comfort has not been reviewed in its entirety. This review seeks to collate known information in a systematic format and provide a framework for patient comfort during regional anesthesia.
