1.
J Org Chem
; 74(21): 8373-6, 2009 Nov 06.
Article
in English
| MEDLINE
| ID: mdl-19777999
ABSTRACT
Calcium D-glucarate was converted into D-glucaro-1,4:6,3-dilactone on 32-g, 1-kg, and 22-kg scale, using azeotropic distillation with methyl isobutyl ketone to drive the dehydration. The crystalline product was > or = 99.5% pure by GC and NMR, and overall yield was as high as 72%.
