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J Biol Chem ; 275(21): 15685-90, 2000 May 26.
Article in English | MEDLINE | ID: mdl-10748193

ABSTRACT

The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families. Here we show that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), and several genes involved in processes related to energy metabolism and vascular disease. Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia.


Subject(s)
Carrier Proteins/metabolism , Lipid Metabolism , Zinc Fingers/genetics , Alternative Splicing/genetics , Apolipoproteins/metabolism , Binding Sites , Carrier Proteins/genetics , Cell Line , Chromosome Mapping , Chromosomes, Human, Pair 11 , DNA-Binding Proteins/genetics , DNA-Binding Proteins/metabolism , Databases, Factual , Gene Expression Regulation , Genetic Linkage , Humans , Hyperlipidemias/etiology , Hyperlipidemias/genetics , Repressor Proteins/genetics , Repressor Proteins/metabolism , Sequence Alignment , Transcription Factors/genetics , Transcription Factors/metabolism , Utah
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