Fallout radionuclide-based techniques for assessing the impact of soil conservation measures on erosion control and soil quality: an overview of the main lessons learnt under an FAO/IAEA Coordinated Research Project.

This paper summarizes key findings and identifies the main lessons learnt from a 5-year (2002-2008) coordinated research project (CRP) on "Assessing the effectiveness of soil conservation measures for sustainable watershed management and crop production using fallout radionuclides" (D1.50.08), organized and funded by the International Atomic Energy Agency through the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. The project brought together nineteen participants, from Australia, Austria, Brazil, Canada, Chile, China, Japan, Morocco, Pakistan, Poland, Romania, Russian Federation, Turkey, United Kingdom, United States of America and Vietnam, involved in the use of nuclear techniques and, more particularly, fallout radionuclides (FRN) to assess the relative impacts of different soil conservation measures on soil erosion and land productivity. The overall objective of the CRP was to develop improved land use and management strategies for sustainable watershed management through effective soil erosion control practices, by the use of ¹³7Cs (half-life of 30.2 years), ²¹°Pb(ex) (half-life of 22.3 years) and 7Be (half-life of 53.4 days) for measuring soil erosion over several spatial and temporal scales. The environmental conditions under which the different research teams applied the tools based on the use of fallout radionuclides varied considerably--a variety of climates, soils, topographies and land uses. Nevertheless, the achievements of the CRP, as reflected in this overview paper, demonstrate that fallout radionuclide-based techniques are powerful tools to assess soil erosion/deposition at several spatial and temporal scales in a wide range of environments, and offer potential to monitor soil quality. The success of the CRP has stimulated an interest in many IAEA Member States in the use of these methodologies to identify factors and practices that can enhance sustainable agriculture and minimize land degradation.

[Assessment of geometric, biomechanical, and osteodensitometric properties of the ultradistal radius with peripheral quantitative computerized tomography in uremic patients with severe hyperparathyroidism]. / Valutazione delle proprietà geometriche, biomeccaniche e osteodensitometriche del radio ultradistale mediante Tomografia Computerizzata quantitativa periferica nei pazienti uremici affetti da iperparatiroidismo grave.

INTRODUCTION: Bone integrity and mineral status were studied with a noninvasive method in uremic patients with severe secondary hyperparathyroidism undergoing maintenance hemodialysis. MATERIAL AND METHODS: Volumetric cortical and trabecular mineral density (cBMD, tBMD) and bone geometrical properties were evaluated in 16 patients (11 women and 5 men) candidate to parathyroidectomy. Peripheral quantitative Computed Tomography (pQCT) was used to make measurements at the distal radius of the nondominant forearm. Thirty-two age-matched healthy subjects were chosen as a control group. Cortical area (CA), cross-sectional area (Total A), cortical thickness (CThk) and stress strain index (SSI) were assessed as biomechanical parameters. Serum intact PTH levels were assessed with a radioimmunoassay method (IRMA). RESULTS: Both cBMD and tBMD were decreased in all patients and the difference was more significant in women (p < .0004 and p < .009) than in the smaller group of men (p < .01 and p < .01). Serum PTH levels correlated negatively with cBMD (r = .52; p < .01), CThk (r = .51; p < .04), CA (r = .52; p < .03) and SSI (r = .54; p < .02), as well as tBMD (r = .34), though not significantly. Dialysis duration did not significantly correlate with cBMD (r = .33), tBMD (r = .20), CA (r = .31), CThk (r = .40) and SSI (r = .35). As for geometrical and biomechanical parameters, CA, CThk and SSI were significantly different in both male and female uremic patients in comparison with the relative controls. Bone quantitative analysis and three-dimensional (3D) representation with the paraboloid revolution model also demonstrated osteopenia. CONCLUSIONS: pQCT shows significant cortical and trabecular osteopenia in uremic patients with severe secondary hyperparathyroidism. Osteopenia is associated with geometrical and mechanical impairment with consequently increased bone fragility and thus a higher risk of fracture. Prolonged PTH hyperexpression seems to be mainly associated with intracortical porosity and cortical-endosteal resorption. Bone quantitative analysis and 3D representation provide rapid automated information on the cortex mineral status.

G protein signaling events are activated at the leading edge of chemotactic cells.

Directional sensing by eukaryotic cells does not require polarization of chemoattractant receptors. The translocation of the PH domain-containing protein CRAC in D. discoideum to binding sites on the inner face of the plasma membrane reflects activation of the G protein-linked signaling system. Increments in chemoattractant elicit a uniform response around the cell periphery. Yet when cells are exposed to a gradient, the activation occurs selectively at the stimulated edge, even in immobilized cells. We propose that such localized activation, transmitted by the recruitment of cytosolic proteins, may be a general mechanism for gradient sensing by G protein-linked chemotactic systems including those involving chemotactic cytokines in leukocytes.

pQCT (quantitative peripheral tomography) and data evaluation of phosphocalcic metabolism in thalassaemic patients.

pQCT is a method which allows the separate determination of cortical and trabecular bone mineral density in the peripheral skeleton. 21 thalassaemic patients (8 females, 13 males) aged from 10 to 32 years, were examined using pQCT at the ultra distal radius to evaluate SSI (Stress-Strain Index). ALP, serum calcium, hydroxyproline, magnesium, IGF-I, and body surface were determined. The results show a good correlation between cortical BMD and age, concentration of hydroxyproline in urine, serum bone Gla protein, body surface index, bone density of trabecular bone and SSI. Good correlation was found between trabecular bone density and age, IGF-I, BGP and PTH, and between SSI and cortical BMD, age and BSI. The linear relationships between age and cortical and trabecular density show an increase of cortical BMD with age and a decrease of trabecular density with age. The same results were obtained considering trabecular and cortical density versus SSI.

[Leukocyte count and granulocyte function of children under lithium carbonate therapy treated with cytostatic drugs. A pilot study]. / Leukozytenzahl und Granulozytenfunktion zytostatisch behandelter Kinder unter Lithiumcarbonat. Eine Pilotstudie.

The usefullness of lithium carbonate for attenuation of leukopenia due to chemotherapy was studied in a prospective randomized trial. Chemotherapy for solid tumors was applied in a paired manner 24 times without and 24 times with lithiumcarbonate. Simultaneously, nucleotid-dependent functions of granulocytes were examined. An attenuation of leukopenia by lithium was observed. Toxic side effects within the therapeutic range of the serum level (0.3-1.4 mol/l) were not detected. Lithium did not impair adherence, chemotaxis and degranulation of neutrophile granulocytes. The influences of lithium on stem-cell maturation and granulocyte function are discussed.