ABSTRACT
The typical changes of hemostasis indicators in different periods of gestation are described. The analysis of blood plasma in pregnant women with menace of miscarriage and compromised anamnestic record on spontaneous or attempted abortion was made. The valid hypercoagulation deviations are detected. They are manifested in the decrease of international normalized ratio indicators and index of activated partial thromboplastin time, the increase of level of soluble fibrin-monomeric complex against the background of mild hyperfibrinogenemia and decrease of activity of plasminogen, antihtrombin III and protein C. The lupousus anticoagulant and Leiden mutation occurred more often. The evidence of changes differed depending of presence of complications in the anamnesis and current menace of miscarriage. The established thrombofilic shifts can play certain pathogenic role in development of noncarrying of pregnancy.
