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Molecules ; 9(3): 102-8, 2004 Feb 28.
Article in English | MEDLINE | ID: mdl-18007414

ABSTRACT

A series of 9-(pyridin-2'-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.


Subject(s)
Aminoacridines/chemistry , Antineoplastic Agents, Alkylating/chemistry , DNA/chemistry , Pyridines/chemistry , Aminoacridines/chemical synthesis , Amsacrine/chemistry , Animals , Antineoplastic Agents, Alkylating/chemical synthesis , Cattle , Hot Temperature , Humans , Nucleic Acid Denaturation , Pyridines/chemical synthesis , Quantitative Structure-Activity Relationship , Quinacrine/chemistry
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