1.
BMJ
; 363: k5088, 2018 12 05.
Article
in English
| MEDLINE
| ID: mdl-30518540
2.
Crit Care
; 19: 237, 2015 Jun 01.
Article
in English
| MEDLINE
| ID: mdl-26028257
Subject(s)
Cardiac Output/physiology , Leg/blood supply , Leg/physiology , Movement/physiology , Posture/physiology , Humans
3.
BMJ
; 345: e5677, 2012 Aug 24.
Article
in English
| MEDLINE
| ID: mdl-22923534
Subject(s)
Acute Disease/therapy , Critical Illness/therapy , Hospital Units/standards , Medical Staff, Hospital , Monitoring, Physiologic/methods , Patient Care Management/methods , Acute Disease/epidemiology , Clinical Competence/standards , Critical Illness/epidemiology , Health Knowledge, Attitudes, Practice , Humans , Medical Errors/prevention & control , Medical Staff, Hospital/education , Medical Staff, Hospital/standards , Outcome and Process Assessment, Health Care , Patient Care Planning , Quality Improvement , Severity of Illness Index , United Kingdom/epidemiology , Vital Signs
4.
Thorax
; 66(4): 359, 2011 Apr.
Article
in English
| MEDLINE
| ID: mdl-20889520
5.
BMJ
; 341: c6009, 2010 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-21078751
6.
Crit Care
; 14(4): 181, 2010.
Article
in English
| MEDLINE
| ID: mdl-20663182
ABSTRACT
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Macrolides/therapeutic use , Pneumonia, Bacterial/drug therapy , Quorum Sensing/drug effects , Anti-Bacterial Agents/administration & dosage , Community-Acquired Infections/drug therapy , Community-Acquired Infections/microbiology , Drug Therapy, Combination , Humans , Macrolides/administration & dosage , Pneumonia, Bacterial/microbiology
7.
Clin Med (Lond)
; 10(2): 108-9, 2010 Apr.
Article
in English
| MEDLINE
| ID: mdl-20437973
8.
BMJ
; 340: c962, 2010 Apr 13.
Article
in English
| MEDLINE
| ID: mdl-20388691
9.
Chest
; 137(1): 237-8; author reply 238, 2010 Jan.
Article
in English
| MEDLINE
| ID: mdl-20051417
10.
JAMA
; 302(13): 1416; author reply 1416-7, 2009 Oct 07.
Article
in English
| MEDLINE
| ID: mdl-19809020
11.
N Engl J Med
; 361(2): 207; author reply 207-8, 2009 Jul 09.
Article
in English
| MEDLINE
| ID: mdl-19593856
Subject(s)
Asthma/drug therapy , Esomeprazole/adverse effects , Gastroesophageal Reflux/drug therapy , Proton Pump Inhibitors/adverse effects , Stomach/microbiology , Asthma/etiology , Esomeprazole/therapeutic use , Gastroesophageal Reflux/complications , Humans , Hydrogen-Ion Concentration , Proton Pump Inhibitors/therapeutic use , Respiratory Aspiration/complications , Stomach/physiology
12.
Crit Care
; 13(3): 410, 2009.
Article
in English
| MEDLINE
| ID: mdl-19591642
13.
Crit Care
; 12(6): 433, 2008.
Article
in English
| MEDLINE
| ID: mdl-19014675
14.
Crit Care
; 12(3): 419; auhtor reply 419, 2008.
Article
in English
| MEDLINE
| ID: mdl-18492223