ABSTRACT
Sporotrichosis in children is rare, and its osteoarticular form is very unusual. Disseminated forms are described mostly in immunocompromised patients. We report a case of a 5-year-old immunocompetent boy with multiple suppurated cutaneous lesions that progressed to polyarthritis of the hands and feet. Radiographic imaging demonstrated multifocal lytic lesions. Sporotrichosis was diagnosed through biopsy and culture. This article describes the radiographic appearance of a rare manifestation of this disease. In areas of high prevalence, the diagnosis of sporotrichosis should be taken into account, even in immunocompetent patients, when dactylitis with lytic lesions is present.
Subject(s)
Bone Diseases, Infectious/diagnostic imaging , Bone Diseases, Infectious/microbiology , Sporothrix/isolation & purification , Sporotrichosis/diagnostic imaging , Sporotrichosis/microbiology , Bone Diseases, Infectious/immunology , Child, Preschool , Diagnosis, Differential , Humans , Immunocompetence/immunology , Male , Radiography , Rare Diseases/diagnostic imaging , Rare Diseases/immunology , Rare Diseases/microbiology , Sporotrichosis/immunologyABSTRACT
CASE REPORT: We report a case of choroidal melanoma metastatic to the liver diagnosed by fine-needle aspiration. The biopsy sample was immunostained for COX-2 and c-kit. COMMENTS: Accurate diagnosis and identification of potential therapeutic targets are important for subsequent therapy and can be achieved by radiologically guided fine-needle aspiration biopsy.
Subject(s)
Choroid Neoplasms/metabolism , Cyclooxygenase 2/metabolism , Liver Neoplasms/metabolism , Melanoma/metabolism , Proto-Oncogene Proteins c-kit/metabolism , Aged , Biopsy, Needle , Choroid Neoplasms/pathology , Humans , Immunohistochemistry , Liver Neoplasms/secondary , Male , Melanoma/secondaryABSTRACT
Progressive multifocal leukoencephalopathy is a rare viral-induced demyelinating disease associated to immunodeficiency. A 10-year-old boy with AIDS is reported, who developed subacute cerebellar signs and symptoms with multiple cranial nerve involvement and dementia. A computed tomography scan revealed a focal nonenhancing area of low attenuation in the cerebellum. On magnetic resonance imaging high signal lesions in T2 weighted sequences were shown. The biopsy of one of those lesions showed the typical histological findings of progressive multifocal leukoencephalopathy. It seems important to consider this diagnosis in children with AIDS who present with progressive neurological features.
