ABSTRACT
With the exponential growth of COVID-19 cases, the neurological complications reported during or after the infection became more common. There is limited knowledge regarding the pathophysiological mechanisms that are responsible for these complications. Recent data provides compelling evidence for the neurotropic nature of SARS-CoV-2, based on neurological manifestations reported during the current pandemic, as well as on previous experience with other coronaviruses. We present the case of a patient who developed headaches, motor deficit and dysphasia after respiratory COVID-19. Imaging tests showed heterogeneous central nervous system lesions (multiple subarachnoid hemorrhages and two ischemic strokes). Given the plethora of atypical neurological complications of COVID-19 described in the current literature, establishing a positive diagnosis and deciding on a treatment plan proved to be particularly challenging. We set to discuss some of the possible pathologies, hypothesized to be associated with COVID-19, that could lead to concomitant neurological lesions, similar to those noticed in our patient.
Subject(s)
COVID-19/complications , Nervous System Diseases/diagnosis , Nervous System Diseases/virology , Antibodies, Viral/blood , COVID-19/blood , COVID-19/diagnostic imaging , COVID-19/virology , Computed Tomography Angiography , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Nervous System Diseases/blood , Nervous System Diseases/diagnostic imaging , Pandemics , SARS-CoV-2/physiology , Thorax/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Establishing a diagnosis of Binswanger's disease requires a multimodal approach. As new pathophysiological mechanisms are revealed, tests that should yield greater specificity will become available in the years to come.
