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1.
Proc Natl Acad Sci U S A ; 119(8)2022 02 22.
Article in English | MEDLINE | ID: mdl-35181603

ABSTRACT

High-frequency (HF) signals are ubiquitous in the industrial world and are of great use for monitoring of industrial assets. Most deep-learning tools are designed for inputs of fixed and/or very limited size and many successful applications of deep learning to the industrial context use as inputs extracted features, which are a manually and often arduously obtained compact representation of the original signal. In this paper, we propose a fully unsupervised deep-learning framework that is able to extract a meaningful and sparse representation of raw HF signals. We embed in our architecture important properties of the fast discrete wavelet transform (FDWT) such as 1) the cascade algorithm; 2) the conjugate quadrature filter property that links together the wavelet, the scaling, and transposed filter functions; and 3) the coefficient denoising. Using deep learning, we make this architecture fully learnable: Both the wavelet bases and the wavelet coefficient denoising become learnable. To achieve this objective, we propose an activation function that performs a learnable hard thresholding of the wavelet coefficients. With our framework, the denoising FDWT becomes a fully learnable unsupervised tool that does not require any type of pre- or postprocessing or any prior knowledge on wavelet transform. We demonstrate the benefits of embedding all these properties on three machine-learning tasks performed on open-source sound datasets. We perform an ablation study of the impact of each property on the performance of the architecture, achieve results well above baseline, and outperform other state-of-the-art methods.

2.
Front Neurol ; 11: 579725, 2020.
Article in English | MEDLINE | ID: mdl-33362688

ABSTRACT

Intracranial electroencephalography (EEG) studies using stereotactic EEG (SEEG) have shown that during seizures, epileptic activity spreads across several anatomical regions from the seizure onset zone toward remote brain areas. A full and objective characterization of this patient-specific time-varying network is crucial for optimal surgical treatment. Functional connectivity (FC) analysis of SEEG signals recorded during seizures enables to describe the statistical relations between all pairs of recorded signals. However, extracting meaningful information from those large datasets is time consuming and requires high expertise. In the present study, we first propose a novel method named Brain-wide Time-varying Network Decomposition (BTND) to characterize the dynamic epileptogenic networks activated during seizures in individual patients recorded with SEEG electrodes. The method provides a number of pathological FC subgraphs with their temporal course of activation. The method can be applied to several seizures of the patient to extract reproducible subgraphs. Second, we compare the activated subgraphs obtained by the BTND method with visual interpretation of SEEG signals recorded in 27 seizures from nine different patients. As a whole, we found that activated subgraphs corresponded to brain regions involved during the course of the seizures and their time course was highly consistent with classical visual interpretation. We believe that the proposed method can complement the visual analysis of SEEG signals recorded during seizures by highlighting and characterizing the most significant parts of epileptic networks with their activation dynamics.

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