Review of Computational Techniques for Performance Evaluation of RF Localization Inside the Human Body.

Location estimation within the human body by means of wireless signals is becoming popular for a variety of purposes, including wireless endoscopy using camera pills. The precision of wireless ranging in any medium is contingent upon the methodology employed. Two of the most popular wireless tracking methods are received signal strength (RSS) and time of arrival (TOA). The scope of this study is an assessment of the precision of TOA- and RSS-based ranging in the proximity of anthropomorphic tissue by means of simulation software designed to mimic signal transmission in the human body environment. Software simulations of wireless signals traveling within a human body are exceptionally challenging and require extensive computational resources. We created a rudimentary, MATLAB script using the finite-difference time-domain (FDTD) method to simulate the signal transmission inside and outside a human body and correlated the simulation outcomes of this script with the high-end commercial finite-element method (FEM) tool, ANSYS HFSS. First, we demonstrated that the FDTD modeling produces similar outcomes. Next, we employed the script to emulate the RSS and TOA of the wide bandwidth radio transmission within the human body for wireless ranging and estimated the accuracy of each technology. The precision of both methods was also evaluated with the Cramer-Rao lower bound (CRLB), which is frequently used to estimate the ranging methodologies and the effect of human tissue and its motion.

The Suppressive Effects of the Petroleum Ether Fraction from Atractylodes lancea (Thunb.) DC. On a Collagen-Induced Arthritis Model.

In Chinese traditional medicine, the rhizome of Atractylodes lancea (Thunb.) DC. (A. lancea) is used extensively for the treatment of several diseases such as rheumatic diseases, but its actions on rheumatoid arthritis have not been clarified. The purpose of this article was to investigate the pharmacological effect of an A. lancea rhizome extract on collagen-induced arthritis (CIA) in rats. The CIA model was induced by the injection of bovine type II collagen. The rats were orally administered the petroleum ether (PE) fraction of the A. lancea rhizome (0.82 and 1.64 mg/kg), methotrexate (0.3 mg/kg body weight), or a vehicle from day 7 to day 15 after the model was established. The histological examination and radiological observation showed that the PE fraction significantly reduced the inflammatory responses and collagen loss in the joints of the rats with CIA. The PE fraction inhibited the production of tumor necrosis factor-α, interleukin (IL)-1ß, IL-17, and IL-6 in the sera. Moreover, the treatment with the PE fraction in vivo was able to reduce the level of Beclin 1 protein in the synovial tissue of the rats. These results highlight the antiarthritic potential of the PE fraction of the A. lancea rhizome and provide further evidence of the involvement of Beclin 1 inhibition in the effects of the PE fraction of the A. lancea rhizome. Copyright © 2016 John Wiley & Sons, Ltd.