ABSTRACT
Scientific digital libraries speed dissemination of scientific publications, but also the propagation of invalid or unreliable knowledge. Although many papers with known validity problems are highly cited, no auditing process is currently available to determine whether a citing paper's findings fundamentally depend on invalid or unreliable knowledge. To address this, we introduce a new framework, the keystone framework, designed to identify when and how citing unreliable findings impacts a paper, using argumentation theory and citation context analysis. Through two pilot case studies, we demonstrate how the keystone framework can be applied to knowledge maintenance tasks for digital libraries, including addressing citations of a non-reproducible paper and identifying statements most needing validation in a high-impact paper. We identify roles for librarians, database maintainers, knowledgebase curators, and research software engineers in applying the framework to scientific digital libraries.
ABSTRACT
Systematic reviews answer specific questions based on primary literature. However, systematic reviews on the same topic frequently disagree, yet there are no approaches for understanding why at a glance. Our goal is to provide a visual summary that could be useful to researchers, policy makers, and health care professionals in understanding why health controversies persist in the expert literature over time. We present a case study of a single controversy in public health, around the question: "Is reducing dietary salt beneficial at a population level?" We define and visualize three new constructs: the overall evidence base, which consists of the evidence summarized by systematic reviews (the inclusion network) and the unused evidence (isolated nodes). Our network visualization shows at a glance what evidence has been synthesized by each systematic review. Visualizing the temporal evolution of the network captures two key moments when new scientific opinions emerged, both associated with a turn to new sets of evidence that had little to no overlap with previously reviewed evidence. Limited overlap between the evidence reviewed was also found for systematic reviews published in the same year. Future work will focus on understanding the reasons for limited overlap and automating this methodology for medical literature databases.
ABSTRACT
Self-assembly of the binary molecular system of pentacene and 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) on Ag(111) has been investigated by low-temperature scanning tunneling microscopy, molecular dynamics (MD), and density functional theory (DFT) calculations. Well-ordered two-dimensional (2D) pentacene:PTCDA supramolecular chiral networks are observed to form on Ag(111). The 2D chiral network formation is controlled by the strong interfacial interaction between adsorbed molecules and the underlying Ag(111), as revealed by MD and DFT calculations. The registry effect locks the adsorbed pentacene and PTCDA molecules into specific adsorption sites due to the corrugation of the potential energy surface. The 2D supramolecular networks are further constrained through the directional CO...H-C multiple intermolecular hydrogen bonding between the anhydride groups of PTCDA and the peripheral aromatic hydrogen atoms of the neighboring pentacene molecules.
