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Aging (Albany NY) ; 13(12): 16713-16732, 2021 06 24.
Article in English | MEDLINE | ID: mdl-34170849

ABSTRACT

Ferroptosis, a form of programmed cell death induced by excess iron-dependent lipid peroxidation product accumulation, plays a critical role in cancer. However, there are few reports about ferroptosis in endometrial cancer (EC). This article explores the relationship between ferroptosis-related gene (FRG) expression and prognosis in EC patients. One hundred thirty-five FRGs were obtained by mining the literature, retrieving GeneCards and analyzing 552 malignant uterine corpus endometrial carcinoma (UCEC) samples, which were randomly assigned to training and testing groups (1:1 ratio), and 23 normal samples from The Cancer Genome Atlas (TCGA). We established a signature using eight screened FRGs (MDM2, GPX4, PRKAA2, PRNP, SLC11A2, ATP5MC3, PHKG2 and ACO1) related to overall survival using LASSO regression analysis. The samples were divided into low- and high-risk subgroups according to the median risk score. Kaplan-Meier survival curves showed that the low-risk group had better OS. ROC curves showed that this signature performed well in predicting OS (1-, 2-, 3-, and 5-year AUCs of 0.676, 0.775, 0.797, and 0.826, respectively). We systematically analyzed the immune infiltrating profile in UCEC samples from TCGA. Overall, our study identified a novel prognostic signature of 8 FRGs that can potentially predict the prognosis of EC.


Subject(s)
Endometrial Neoplasms/genetics , Endometrial Neoplasms/immunology , Ferroptosis/genetics , Gene Expression Profiling , Lymphocytes, Tumor-Infiltrating/metabolism , Cohort Studies , Databases, Genetic , Female , Gene Expression Regulation, Neoplastic , Genetic Variation , Humans , Molecular Sequence Annotation , Principal Component Analysis , Prognosis , Protein Interaction Maps/genetics , Reproducibility of Results , Risk Factors
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