ABSTRACT
Circulatory indirect calorimetry (CIC) is a potentially useful method to assess the energy requirements of critically ill patients. Unlike respiratory indirect calorimetry (RIC), which measures oxygen utilization from inhaled and exhaled gases, CIC measures oxygen utilization from arterial and mixed venous blood. Twenty-two measurements in eight critically ill patients comparing RIC, CIC, and commonly used estimates of energy expenditure were performed. A significant correlation between RIC and CIC was identified (r = 0.831, p less than 0.001). Poor correlation was noted with either method and the commonly used estimates. CIC may be a useful tool in estimating energy expenditures in the critically ill.
Subject(s)
Calorimetry, Indirect/methods , Critical Illness , Aged , Aged, 80 and over , Energy Metabolism , Evaluation Studies as Topic , Humans , Middle Aged , Nutritional RequirementsABSTRACT
To determine the value of transbronchial needle aspiration biopsy in the diagnosis of sarcoidosis, we reviewed a 1-year experience of consecutive patients with sarcoidosis presenting with hilar and/or paratracheal adenopathy. The sensitivity of transbronchial needle aspiration biopsy in obtaining specimens of noncaseating granulomas was 90%. This yield exceeds that of most published reports of transbronchial lung biopsy and bronchial mucosal biopsy and suggests that transbronchial needle aspiration biopsy may be a valuable diagnostic tool in the evaluation of these forms of sarcoidosis.
Subject(s)
Biopsy, Needle/methods , Lung Diseases/diagnosis , Sarcoidosis/diagnosis , Bronchoscopy/methods , Fiber Optic Technology , Humans , Lung/pathologySubject(s)
Lung Neoplasms/pathology , Melanoma/pathology , Bronchoscopy , Humans , Male , Melanoma/secondary , Middle AgedABSTRACT
Hypothyroidism is not commonly associated with acanthosis nigricans (AN). We examined a 13-year-old girl with AN, hypertrichosis, and Hashimoto's thyroiditis. Overt biochemical hypothyroidism, thyroid enlargement, and positive titers of antimicrosomal and antithyroglobulin antibodies confirmed Hashimoto's thyroiditis. Both AN and hypertrichosis resolved with thyroid hormone replacement. There was no evidence of insulin resistance, polycystic ovarian disease, lipoatrophy, or other endocrine dysfunction, or of malignancy. In two patients from the literature with AN and hypothyroidism, AN was attributed to associated thyroid carcinoma or insulin resistance, rather than coexisting hypothyroidism. Since the skin lesions improved with thyroid hormone therapy in those two patients and in ours, hypothyroidism appears to be directly involved in the pathogenesis of AN.
Subject(s)
Acanthosis Nigricans/drug therapy , Hypertrichosis/drug therapy , Thyroiditis, Autoimmune/drug therapy , Thyroxine/therapeutic use , Acanthosis Nigricans/etiology , Adolescent , Female , Humans , Hypertrichosis/etiology , Hypothyroidism/complicationsABSTRACT
Fibrinolytic agents have been advocated for the treatment of massive pulmonary emboli. The usual mode of infusion is via a peripheral vein. Theoretically, infusion into the pulmonary artery would be expected to be more efficacious. A case representing the failure of intra-pulmonary artery infusion of fibrinolytic agents is presented. However, a literature review suggests that this mode of therapy may achieve a greater success in clot lysis than does peripheral infusion. Additionally, this form of treatment may allow the clinician to lower the administered dose which may represent an advantage to the patient.
