ABSTRACT
A 51-year-old woman with carcinoma of the right axillary sweat glands was treated by radical surgery and radiotherapy. Six years later she developed multiple bilateral lung metastases. Nine nodes were resected from both lungs using a clamshell approach (bilateral transsternal, anterolateral thoracotomy). After surgery, the patient received 6 cycles of adjuvant chemotherapy with cisplatin and 5-fluoruracil. Three years after treatment, no intrathoracic recurrences had occurred and the patient was asymptomatic, with good quality of life.
Subject(s)
Adenocarcinoma/secondary , Adenocarcinoma/surgery , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Sweat Gland Neoplasms , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/drug therapy , Antimetabolites, Antineoplastic/therapeutic use , Antineoplastic Agents/therapeutic use , Axilla , Chemotherapy, Adjuvant , Cisplatin/therapeutic use , Combined Modality Therapy , Female , Fluorouracil/therapeutic use , Follow-Up Studies , Humans , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/drug therapy , Lymph Node Excision , Middle Aged , Radiography, Thoracic , Thoracotomy , Time Factors , Tomography, X-Ray ComputedABSTRACT
Mujer de 51 años con un carcinoma de glándulas sudoríparas (CGS) en la axila derecha tratado mediante cirugía radical y radioterapia, que 6 años después presentó metástasis pulmonares bilaterales múltiples. Se resecaron nueve nódulos en ambos pulmones a través de una toracotomía anterolateral bilateral transesternal (clamshell). La paciente recibió seis ciclos de quimioterapia adyuvante postoperatoria con cisplatino y 5-fluorouracilo. En la actualidad, a los 3 años de seguimiento, no ha habido recidivas intratorácicas, y la paciente se encuentra asintomática y con buena calidad de vida (AU)
Subject(s)
Middle Aged , Female , Humans , Sweat Gland Neoplasms , Tomography, X-Ray Computed , Radiography, Thoracic , Thoracotomy , Time Factors , Chemotherapy, Adjuvant , Antimetabolites, Antineoplastic , Axilla , Antineoplastic Agents , Combined Modality Therapy , Cisplatin , Adenocarcinoma , Lymph Node Excision , Fluorouracil , Follow-Up Studies , Lung NeoplasmsABSTRACT
Recently tumors have been reported that have an architectural pattern and cellularity similar to hyalinizing trabecular adenoma and show either parafollicular differentiation or histological findings suggestive of malignant neoplasm of the follicular cells. This study describes two cases of thyroid carcinoma of follicular cells that displayed a hylinizing trabecular pattern. The first case was a 25-year-old euthyroid woman with a cold thyroid nodule in the right lobe. On fine needle aspiration a diagnosis of papillary carcinoma was rendered. The thyroidectomy disclosed a 2-cm, firm, brown, encapsulated tumor in the right lobe. The tumor had a growth pattern and cytologic features similar to those described in hyalinizing trabecular adenoma. The differences between these neoplasms were the presence of mitotic figures, prominence of the nucleolus, capsular blood vessel invasion, and microtubule groups in the endoplasmic reticulum. The second case was a 19-year-old euthyroid woman with a cold thyroid nodule in the left lobe. A cytologic diagnosis of follicular proliferation was rendered. A 4-cm, firm, whitish, encapsulated nodule was found in the left lobectomy. The tumor cells were arranged in two clear-cut patterns: a trabecular hyalinizing pattern with a small focus of papillary growth, and a follicular pattern. These findings confirm the existence of malignant thyroid tumors with a hyalinizing trabecular pattern and illustrate the nonspecificity of this peculiar pattern, since it may also be seen in papillary carcinomas of the thyroid. The relationship between hyalinizing trabecular adenoma and papillary carcinoma of the thyroid is commented on.
Subject(s)
Adenocarcinoma, Follicular/pathology , Thyroid Neoplasms/pathology , Adenocarcinoma, Follicular/ultrastructure , Adult , Female , Humans , Immunohistochemistry , Microscopy, Electron , Thyroid Neoplasms/ultrastructureABSTRACT
A case of neurilemoma of the left breast in an 83-year-old man is presented, including the fine needle aspiration and biopsy diagnosis. A review of the literature did not reveal the existence of such a tumor in a man's breast. The aspirate yielded a cellular smear composed of clusters of spindle-shaped cells showing minimal atypia and Verocay bodies. The final diagnosis was established on the excised mass through histopathologic study.
