[In vitro stimulation of Leydig cells with human chorionic gonadotropin in adult rats of different ages]. / Estimulación in vitro de las células de Leydig con gonadotrofina coriónica humana en ratas adultas de diferentes edades.

We studied the functional reserve of Leydig cells in adult rats of different ages in vitro. Suspensions of Leydig cells after digestion by collagenase were stimulated with Human Chorionic Gonadotropin (hCG) during different times (1, 3 and 5 hours). We observed that response of Leydig cells, expressed by the testosterone concentration in the culture medium, showed a similar pattern in all studied group, and the highest response was seen at three hours of incubation. On the other hand, the testosterone response to hCG varied with age of animal. Thus, it was higher in the group of 14 months old (middle aged) than young animals (5 month old) and decreased in old animals (21 months old). These results suggest that a primary testicular lesion occurs with aging.

Contenido de estrogenos en cremas faciales. / Content of estrogens in facial creams

En pacientes con sintomatologia mamaria como tension premenstrual y mastodinia, observamos relacion con el empleo reciente de cremas faciales de "belleza". El estudio de estas cremas por RIA demostro en 6 de las 7 cremas estudiadas un contenido de estradiol variable, en una de las cremas fue tan alto que alcanzo 1683 pg/gr de crema. Se hace una revision somera sobre las ventajas e inconvenientes de la absorcion de estrogenos por la piel y se recomienda que el Ministerio de Sanidad tome las medidas necesarias para la proteccion del publico consumidor