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2.
Yakugaku Zasshi ; 133(11): 1235-41, 2013.
Article in Japanese | MEDLINE | ID: mdl-24189564

ABSTRACT

In recent years there have been over 30000 suicides annually in Japan. This is one of the most serious problems for Japanese society. Because mental disorder is closely associated with suicide, factors related to the increase in mental disorders and suicides should be clarified. In this study, various data regarding social factors were evaluated to assess the correlation of the number of patients with mental disorders and suicides among the 47 prefectures of Japan. Various data regarding social factors, such as income, savings, or rate of divorce, were obtained from the database of the Ministry of Health, Labour and Welfare of Japan. Among the factors, the annual income and the amount of savings were significantly correlated with the number of patients with mental disorder. On the other hand, while the annual income did not have a significant correlation with suicides, the amount of savings had a significant correlation with suicides. In conclusion, the annual income and amount of savings may both be one of the important factors involved in mental disorders, and the savings may also be a factor affecting suicides. These analyses are valuable in helping to clarify the causes of mental disease, and can hopefully contribute to the health and welfare of Japanese.


Subject(s)
Income , Mental Disorders , Suicide , Humans , Japan , Mental Disorders/epidemiology , Outpatients , Population Density , Socioeconomic Factors , Suicide/statistics & numerical data
3.
Hum Genet ; 131(2): 235-50, 2012 Feb.
Article in English | MEDLINE | ID: mdl-21769484

ABSTRACT

We describe a male patient (patient DGAP113) with a balanced translocation, 46,XY,t(1;3)(q31.3;q13.13), severe bilateral congenital cataracts, CNS abnormalities and mild developmental delay. Fluorescence in situ hybridization (FISH) and suppression PCR demonstrated that the chromosome 3 breakpoint lies ~515 kb upstream of the PVRL3 gene, while the chromosome 1 breakpoint lies ~50 kb upstream of the NEK7 gene. Despite the fact that NEK7 is closer to a translocation breakpoint than PVRL3, NEK7 transcript levels are unaltered in patient DGAP113 lymphoblastoid cells and Nek7-deficient mice exhibit no detectable ocular phenotype. In contrast, the expression of PVRL3, which encodes the cell adhesion protein Nectin 3, is significantly reduced in patient DGAP113 lymphoblastoid cells, likely due to a position effect caused by the chromosomal translocation. Nectin 3 is expressed in the mouse embryonic ciliary body and lens. Moreover, Pvrl3 knockout mice as well as a spontaneous mouse mutant ari (anterior retinal inversion), that maps to the Pvrl3 locus, exhibit lens and other ocular defects involving the ciliary body. Collectively, these data identify PVRL3 as a critical gene involved in a Nectin-mediated cell-cell adhesion mechanism in human ocular development.


Subject(s)
Cataract/congenital , Cataract/genetics , Cell Adhesion Molecules/genetics , Animals , Cell Adhesion Molecules/metabolism , Cell Line , Chromosome Breakage , Humans , Lymphocytes , Male , Mice , Mutation , NIMA-Related Kinases , Nectins , Protein Serine-Threonine Kinases/metabolism , Translocation, Genetic
4.
Hum Genet ; 114(5): 448-57, 2004 Apr.
Article in English | MEDLINE | ID: mdl-14767757

ABSTRACT

There is an assumption of parsimony with regard to the number of chromosomes involved in rearrangements and to the number of breaks within those chromosomes. Highly complex chromosome rearrangements are thought to be relatively rare, with the risk for phenotypic abnormalities increasing as the number of chromosomes and chromosomal breaks involved in the rearrangement increases. We report here five cases of de novo complex chromosome rearrangements, each with a minimum of four breaks. Deletions were found in four cases, and in at least one case, a number of genes or potential genes might have been disrupted. This study highlights the importance of the detailed delineation of complex rearrangements, beginning with high-resolution chromosome analysis, and emphasizes the utility of fluorescence in situ hybridization in combination with the data available from the Human Genome Project as a means to delineate such rearrangements.


Subject(s)
Abnormalities, Multiple/genetics , Chromosome Aberrations , Chromosome Disorders/genetics , Gene Rearrangement/genetics , Adult , Cell Line , Child, Preschool , Chromosome Banding , Chromosomes, Artificial, Bacterial , Cosmids , Female , Humans , In Situ Hybridization, Fluorescence , Infant, Newborn , Karyotyping , Male
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