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J Public Health Dent ; 66(3): 174-9, 2006.
Article in English | MEDLINE | ID: mdl-16913243

ABSTRACT

OBJECTIVES: To assess the effects of a single 10% povidone iodine application as an adjunct to extensive surgical procedures in the clinical treatment of children with early childhood caries. METHODS: Twenty-two children scheduled for dental treatment under general anesthesia were randomized into either an intervention group (10% povidone iodine), or a control group (phosphate buffered saline). Either povidone iodine or phosphate buffered saline was applied to teeth and soft tissues after prophylaxis and all operative dental procedures, followed by 1.23% acidulated phosphate fluoride gel. Saliva samples taken at baseline, and after 1 hour, 3 weeks and 3 months were assayed for mutans streptococci, lactobacilli and total viable bacteria. Caries lesions were recorded at baseline and at one year. RESULTS: Mutans streptococci and lactobacilli levels in the povidone iodine group were significantly reduced relative to baseline at 1 hour, 3 weeks and 3 months. At one year at least 60% of subjects had new caries lesions in each group, and there was no significant difference in caries increment between the two groups. CONCLUSIONS: Even prophylaxis, fluoride gel application and complete surgical treatment of caries at baseline were insufficient to prevent new caries in over 60% of the patients in these high caries risk infants. Although the one-time treatment with povidone iodine reduced mutans streptococci and lactobacilli levels for up to 3 months this therapy failed to additionally reduce future caries formation over one year, indicating that repeated antibacterial treatments will be needed to control high levels of cariogenic bacteria.


Subject(s)
Anti-Infective Agents, Local/therapeutic use , Dental Caries/drug therapy , Povidone-Iodine/therapeutic use , Saliva/microbiology , Child , Child, Preschool , Colony Count, Microbial , Dental Caries/microbiology , Dental Caries/prevention & control , Epidemiologic Methods , Humans , Lactobacillus/drug effects , Lactobacillus/isolation & purification , Streptococcus mutans/drug effects , Streptococcus mutans/isolation & purification
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