ABSTRACT
We investigated the significance of a pool of mucin, individually termed mucinous component (MUC), at the leading invasion edge of colorectal submucosal invasive carcinoma (SIC). In particular, we studied the correlation between pathological adverse prognostic factors and stainability of the mucosubstances and tumor-associated glycoconjugates in MUC. We demonstrated that MUCs were present in 21% of SICs, and 20% of SICs with MUC were involved in metastasis or recurrence, while only 6% of SICs without MUC were positive for it (p=0.005). SICs with MUC showed strong staining of carcinoembryonic antigen and Ulex europaeus I in the MUCs as well as in the cancer cells with high-grade atypia. Moreover, the mucins in MUCs predominantly stained for sialomucin. This study was the first to investigate the importance of mucous nodules in colorectal SIC. We concluded that MUC in SIC would be an important adverse prognostic factor, and that we should at least consider employing a similar treatment strategy for it to advanced colorectal carcinoma.
Subject(s)
Carcinoma/pathology , Colonic Neoplasms/pathology , Intestinal Mucosa/pathology , Mucins/analysis , Plant Lectins , Rectal Neoplasms/pathology , Adenocarcinoma/pathology , Adenocarcinoma/secondary , Biomarkers, Tumor/analysis , Carcinoembryonic Antigen/analysis , Carcinoma/secondary , Coloring Agents , Glycoconjugates/analysis , Goblet Cells/pathology , Humans , Lectins/analysis , Lymphatic Metastasis/pathology , Neoplasm Invasiveness , Neoplasm Recurrence, Local/pathology , Prognosis , SialomucinsABSTRACT
Extra-arterial dislocation of a catheter is one of the complications with hepatic arterial infusion chemotherapy. The authors report a case of sepsis related to catheter tip dislocation to the duodenal bulb. A 69-year-old man underwent sigmoidectomy for sigmoid colon cancer and partial hepatectomy for synchronous metastasis to the liver. We performed hepatic arterial catheterization via the femoral artery, and the patient underwent prophylactic hepatic arterial infusion chemotherapy with 5-FU. Thirty months later, computed tomography during arteriography (CTA) using a port system revealed the dislocation of catheter tip to the duodenal bulb. He showed no symptoms, so we kept him under observation. Sepsis occurred because of the dislocated catheter 39 months later. After removal of the catheter, the symptoms of sepsis disappeared.
Subject(s)
Catheterization/adverse effects , Infusions, Intra-Arterial/adverse effects , Infusions, Intra-Arterial/instrumentation , Liver Neoplasms/drug therapy , Sepsis/etiology , Aged , Equipment Failure , Hepatic Artery , Humans , Liver Neoplasms/secondary , Male , Sigmoid Neoplasms/pathology , Sigmoid Neoplasms/surgeryABSTRACT
We report in this article a new technique of surgical treatment of enterocutaneous or enterovaginal fistula after total cystectomy for three cases of bladder cancer. The surgical outcome was successful in these patients, showing good performance status after this operation. It would seem that this technique is a good indication for enteric fistulas in the bottom of the pelvic cavity, which were difficult to be managed even under the control of total parenteral nutrition.
