Tomato Juice Consumption Could Improve Breast Skin Adverse Effects of Radiotherapy in Breast Cancer Patients.

BACKGROUND/AIM: We investigated the beneficial effects of drinking tomato juice (TJ) rich in antioxidant carotenoids on irradiated skin following radiotherapy (RT) in breast cancer patients. PATIENTS/METHODS: Twenty-three patients agreed to drink TJ (160 g/day for six months) after the completion of RT. Early and late adverse events (AEs) of irradiated skin were evaluated according to the Common Terminology Criteria for AEs and the European Organization for Research and Treatment of Cancer Global Cosmetic Rating System, respectively. RESULTS: With regard to early AEs, acute radiodermatitis of grade 1 was observed in most patients (22/23) at the end of RT. However, the grade of radiodermatitis rapidly changed to 0, 1 month after RT and starting TJ consumption. With regard to late AEs, most patients were in good or excellent dermal condition. CONCLUSION: TJ consumption could help in relieving and recovering from early AEs and decreasing the severity of late AEs of irradiated skin.

Quantitative assessment of radiodermatitis through a non-invasive objective procedure in patients with breast cancer.

Assessment of skin condition is necessary for providing advice regarding skin self-care to patients with breast cancer who have undergone radiation therapy. Acute and chronic phases of radiodermatitis were analyzed in patients using objective assessment tools in the present study. A total of 18 women who received radiation therapy for breast cancer were enrolled in the present study and their skin surface temperature (SST), hydration level of the skin surface (HL), melanin intensity (MI) and erythema intensity (EI) were measured prior to radiation therapy and six months thereafter. Furthermore, skin condition was assessed using the Common Terminology Criteria for Adverse Events (CTCAE). EI and MI levels at the irradiated site peaked upon the completion of radiation therapy and declined to baseline at 6 months. In contrast, SST levels were elevated at the irradiated site during radiation therapy (P<0.05) and plateaued after its completion. The same parameters in non-irradiated control sites remained unchanged during the study period. HL reached the minimum in irradiated and non-irradiated sites upon completion of radiation therapy. Although HL returned to baseline in the non-irradiated site 6 months after radiation therapy, it remained low in the irradiated site. No relationship between the CTCAE and EI level was observed. In conclusion, the present study demonstrated that objective assessment tools, including SST and EI levels, were useful for assessing skin condition during radiodermatitis. The combination of the CTCAE and objective assessment tools will enable a more accurate assessment of radiodermatitis.

Mental and physical stress of the Fukushima disaster evacuees as estimated by the measurement of urinary 8-hydroxy-2'-deoxyguanosine.

Following the accident at the Fukushima Daiichi Nuclear Power Plant in 2011, a number of evacuees were forced to live in temporary housing and suffered mental and physical stress. However, few reports have used objective or quantitative indicators to determine the evacuee's level of stress. The aim of the present study was to serially estimate the mental and physical stress of the evacuees from 2013 to 2015 by using the oxidative stress marker, urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). A total of 773 evacuees from Namie town in Fukushima prefecture participated in the study. In the first year, 486 evacuees participated (age, 62.8±18.2 years; male/female, 217/269). Of these, 127 continually participated in the study for 3 years (age, 69.5±13.5 years; males/female 52/75) and 18.1% had no chronic disease after the first year. Urine samples were collected once per year. Urinary 8-OHdG was measured using immunochromatography and corrected by the concentration of urinary creatinine. For all the participants examined each year, mean values of urinary 8-OHdG significantly increased over time. For the 127 continual participants, mean values of urinary 8-OHdG were significantly higher in 2014 and 2015 than those in 2013. Age, gender and presence of chronic disease did not significantly influence the 8-OHdG values, suggesting that the stress level of the evacuees was not associated with these factors. The stress level of the individuals increased with the length of time spent living in the temporary housing. The evacuees in radiation disasters have different stressors from other natural disasters, which may accelerate mental and physical stress.