ABSTRACT
The aim of the study was to discuss the results of thermoluminescent dosimetry (TLD) in rotary-dual technique of the total skin electron irradiation (TSEI RD), to confirm beam calibration and monitor unit calculations and to provide data for making clinical decisions. Between May 2001 and April 2002, in 3 cases of mycosis fungoides, 736 dosimetric checks were performed in 34 points at the skin. CaF2:MnTLD-400 cubes (1/8"x1/8"x0.015") were used for in vivo dosimetry. Doses were computed and analyzed for all locations. Percent of described dose and SD for the following localizations from 34 points were: anterior abdomen (reference point) 100+/-6%, upper back 100+/-8%, right calf 98+/-10%, left foot (mid dorsum) 97+/-8%, posterior neck 93+/-6%, right hand (mid dorsum) 78+/-10%, hand fingers 57+/-10%, top of right shoulder 56+/-14%, left groin 35+/-20%, perineum 22+/-17%. The correlations between patient's height and measured doses were sufficient for the following localizations: scalp (top rear), occiput, elbows, hand fingers and hands (mid dorsum). The correlations between obesity index and measured doses were sufficient for the following localizations: shoulders and lateral neck, groins, and perineum. Dosimetric checks at the reference point confirm that our beam calibration technique and monitor unit calculation are accurate. TLD shows that for some parts of the skin such as shoulder, hands and perineum boost fields were required. The correlations with obesity index and height for several sites suggest that boost fields must be customized for each patient.
Subject(s)
Electrons , Skin/radiation effects , Thermoluminescent Dosimetry/methods , Adult , Female , Humans , MaleABSTRACT
Nasopharyngeal carcinoma constitute 0.3% all malignancies in Poland. These tumors still pose a complex diagnostic problem. Intracranial structures and facial skeleton have not been accessible for X-ray imaging so far. Improvement o imaging techniques, fibroscopy, computed tomography, magnetic resonance imaging allows for gathering new data which influence diagnostics and treatment planning in this difficult anatomical localization. Development of radiotherapy techniques allows for decreasing of radio-reaction and neighbouring structure damage. 188 patient were included in this series and divided into two subgroups: I--128 patients treated between 1980-1990 and II--60 patients between 1991-1995. The diagnostics and treatment methods differs in both subgroups. It was connected with new imaging techniques, therapeutic equipment as well as combination of radiotherapy and neoadjuvant chemotherapy. The authors present the latest diagnostic and therapeutic methods which are currently applied in ENT Dept. Karol Marcinkowski University of Medical Sciences and Wielkopolskie Centrum Onkologii with review of literature devoted to the progress in diagnostics, treatment planning and modern radiotherapy techniques.
Subject(s)
Carcinoma, Squamous Cell/therapy , Nasopharyngeal Neoplasms/therapy , Combined Modality Therapy , Female , Humans , Male , Retrospective StudiesABSTRACT
During the years 1989 to 1994, in the Department of General Surgery we performed surgery on 800 cases of large bowel cancer. The cases comprised 412 men (51.5%) and 388 women (48.5%), aged 25 to 85, the most numerous age group ranging from 50 to 70 (60%). Radical surgery was carried out on 501 cases (62.7%) and palliative surgery on 299 cases (37.3%). In cases with histopathological evaluation pTNM-T1N0M0 or T2N0M0 we refrained from chemo- and radiotherapy. In cases of rectal cancer with advanced staging T3N1M0 or T4N2M1 we applied radiotherapy, whereas in cases of cancer localized on other parts of large bowel we had recourse to chemotherapy as combined treatment. Radiotherapy was applied irrespective of grading, whereas chemotherapy was applied in cases of cancer with grading G2 and G3. Radiative energy was used in 65 cases and chemotherapy in 120 cases. Postoperational mortality amounted to 6%. Five years survival after radical surgery achieved 57.4%. Local recurrence took place in 21% of the cases. The control group consisted of the cases subjected to surgery in the years 1984-1989 when only surgery was performed and 5-years survival after radical surgery amounted to 48% and local recurrence was found in 30% of the cases.
Subject(s)
Colorectal Neoplasms/therapy , Adult , Aged , Aged, 80 and over , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Chemotherapy, Adjuvant , Colorectal Neoplasms/mortality , Colorectal Neoplasms/pathology , Combined Modality Therapy , Female , Fluorouracil/administration & dosage , Humans , Levamisole/administration & dosage , Male , Middle Aged , Neoplasm Staging , Palliative Care , Radiotherapy Dosage , Radiotherapy, Adjuvant , Survival RateABSTRACT
Two cases of sarcoidosis with peripheral lymphatic nodes involvement and coexisting toxoplasmosis are presented. Both cases illustrate diagnostic and differentiating problems in patients with chronic lymphatic nodes enlargement and positive serological reaction to T. gondii antigen. An emphasis is on the importance of the histological examination of the lymphatic nodes for the sarcoidosis diagnosis and contribution of T. gondii to the disease. Positive serological reaction to T. gondii antigen in patients with sarcoidosis may reflect inactive toxoplasmosis; however, periodical serological tests are necessary monitoring the due immunosuppressive treatment used in patients with sarcoidosis.
