Subject(s)
Leukemia/epidemiology , Lymphoma/epidemiology , Adolescent , Age Factors , Burkitt Lymphoma/epidemiology , Child , Child, Preschool , Data Interpretation, Statistical , Female , Hodgkin Disease/epidemiology , Humans , Infant , Infant, Newborn , Leukemia, Myeloid, Acute/epidemiology , Linear Models , Lymphoma, Non-Hodgkin/epidemiology , Male , Poisson Distribution , Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology , Registries , Republic of Belarus/epidemiology , Sex FactorsSubject(s)
Astrocytoma/epidemiology , Brain Neoplasms/epidemiology , Central Nervous System Neoplasms/epidemiology , Ependymoma/epidemiology , Glioma/epidemiology , Neuroectodermal Tumors/epidemiology , Adolescent , Age Factors , Astrocytoma/mortality , Brain Neoplasms/mortality , Central Nervous System Neoplasms/mortality , Child , Child, Preschool , Data Interpretation, Statistical , Ependymoma/mortality , Female , Glioma/mortality , Humans , Infant , Infant, Newborn , Male , Neuroectodermal Tumors/mortality , Registries , Republic of Belarus/epidemiology , Sex Factors , Survival AnalysisABSTRACT
Early and late effects of short-living iodine isotopes on the thyroid of children in Byelarus are described. Early effects manifested with an increase in the thyroid functional activity in children up to one year of age during 1986. Follicular cell hypertrophy is considered as a marker of the radiation effect at a dose level from 0.1 to 1 krad. Late effects are thyroid carcinomas the incidence of which in the country rose ten-fold within the last 5 years.
Subject(s)
Air Pollution, Radioactive/adverse effects , Power Plants , Radioactive Hazard Release , Thyroid Gland/pathology , Thyroid Gland/radiation effects , Adolescent , Air Pollution, Radioactive/statistics & numerical data , Autopsy , Child , Child, Preschool , Female , Fetus/pathology , Humans , Infant , Infant, Newborn , Male , Neoplasms, Radiation-Induced/epidemiology , Neoplasms, Radiation-Induced/pathology , Radioactive Hazard Release/statistics & numerical data , Republic of Belarus/epidemiology , Stochastic Processes , Thyroid Neoplasms/epidemiology , Thyroid Neoplasms/pathology , Time Factors , UkraineABSTRACT
Transplantable rat tumours (sarcoma M-1, sarcoma 45, alveolar liver cancer PC-1 and Pliss' lymphosarcoma) were used to study chlorin e6 accumulation in tumours and its photodynamic effect. Tumours were irradiated by krypton ion laser light (647 and 676 nm; 90 J cm-2) 15 min and 24 h after chlorin e6 injection at doses of 5 and 10 mg kg-1. The relationship between some morphological peculiarities of these tumour strains, photosensitizer accumulation in tumours and their response to the photodynamic treatment is discussed.
Subject(s)
Neoplasms, Experimental/drug therapy , Photochemotherapy , Porphyrins/therapeutic use , Radiation-Sensitizing Agents/therapeutic use , Animals , Cell Division/drug effects , Chlorophyllides , Female , Fibrosarcoma/drug therapy , Light , Liver Neoplasms/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Neoplasms, Experimental/pathology , Porphyrins/blood , Porphyrins/toxicity , Rats , Rats, Wistar , Sarcoma, Experimental/drug therapy , Skin/drug effects , Skin/pathologyABSTRACT
Postmortem morphologic examination of the thyroid was performed in 122 residents of the Minsk Region, Byelorussian Republic. Various pathology underdiagnosed during life was found in 68%. Fourteen papillary carcinomas were detected in 11 (9.9%) of cases whereas 27 (22.1%) subjects revealed 46 follicular adenomas. Nodular goiter was established in 52.5%, thyroiditis--6.5% and cancer metastases--in 5.7% of cases. The male/female ratio for microcarcinoma was 8:3. All tumor-bearing subjects were over 41 years of age. Occurrence of the occult thyroid pathology in different regions of the country can be used to compare potential radiation and other hazards.
Subject(s)
Adenoma/secondary , Carcinoma/secondary , Neoplasms, Unknown Primary/pathology , Thyroid Neoplasms/secondary , Adenoma/epidemiology , Adenoma/pathology , Adult , Age Factors , Aged , Autopsy/statistics & numerical data , Carcinoma/epidemiology , Carcinoma/pathology , Female , Humans , Male , Middle Aged , Neoplasms, Unknown Primary/epidemiology , Republic of Belarus/epidemiology , Sex Factors , Thyroid Gland/pathology , Thyroid Neoplasms/epidemiology , Thyroid Neoplasms/pathologyABSTRACT
Morphological changes in rat sarcoma M-1 after photodynamic treatment with chlorin e6 were studied. The frequency of necrosis appearance and the depth of its spreading in tumor tissue were evaluated after intraperitoneal injection of chlorin e6 in doses of 1-10 mg kg-1 and subsequent irradiation by a krypton laser with light energy density 22.5-135 J cm-2, using the method of vital staining with Evans blue. It was found that the antitumoral effect of photodynamic treatment was strengthened by increasing the dose of the agent and light and reduced by increasing the time interval between chlorin e6 injection and light irradiation. The treatment being given in the parameters mentioned produced a depth of tumor necrosis which varied from 4.0 mm to 16.6 mm. The mechanisms of tumor tissue damage after photodynamic treatment in vivo are discussed.
Subject(s)
Phototherapy/methods , Porphyrins/pharmacology , Radiation-Sensitizing Agents , Sarcoma, Experimental/radiotherapy , Animals , Cell Survival , Chlorophyllides , Lasers , Necrosis , Rats , Sarcoma, Experimental/blood supply , Sarcoma, Experimental/pathologyABSTRACT
The paper is concerned with morphometric evaluation of changes in Ehrlich mouse solid carcinoma after a separate, dual and combined use of x-ray irradiation, induced hyperglycemia (IH) and local hyperthermia (HT), using two-staged quantitative analysis of tumor tissue injuries. A portion of viable tissue was determined at the first stage, and the density of location of undestroyed tumor cells was evaluated at the second stage. The general result was characterized by the product of these indices. Disorders in the tumor tissue structure were noted in 24 h, the main damage being done by IH and HT in the center of a tumor. In 48 h the total effect was on the increase only in groups with irradiation as a result of cell death in the peripheral zone. In the double use of the agents their combined effect was less than the additive one, and the combined use of all three methods resulted in obvious synergism, and the number of viable tumor cells (by morphological criteria) was decreased by more than two orders.
Subject(s)
Blood Glucose , Carcinoma, Ehrlich Tumor/therapy , Hyperthermia, Induced , Animals , Carcinoma, Ehrlich Tumor/pathology , Carcinoma, Ehrlich Tumor/radiotherapy , Combined Modality Therapy , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Time FactorsABSTRACT
The experience of treatment of 40 patients with locally-advanced soft tissue sarcoma of the limbs. Treatment included preoperative chemoradiotherapy in combination with electromagnetic hyperthermia. As a result, 38 (95%) patients showed marked response which allowed radical limb-saving surgery whereas in 2 (5%) amputation was performed. Adjuvant chemotherapy was used for anaplastic tumors. Five-year survival rate was 64.7 +/- 6.7%.
Subject(s)
Sarcoma/therapy , Soft Tissue Neoplasms/therapy , Adolescent , Adult , Aged , Amputation, Surgical , Antineoplastic Agents/therapeutic use , Combined Modality Therapy , Extremities , Follow-Up Studies , Humans , Hyperthermia, Induced , Middle Aged , Sarcoma/radiotherapy , Sarcoma/surgery , Soft Tissue Neoplasms/radiotherapy , Soft Tissue Neoplasms/surgery , Time FactorsABSTRACT
The paper is devoted to assessment of isometronidazole tolerance, used as a radiosensitizer for preoperative irradiation of lung cancer patients, and to characterization of morphological postradiation changes in tissues of carcinomas removed at operation. Isometronidazole was shown to cause no severe side-effects in patients, improving considerably radiation injury of the tumor parenchyma.
Subject(s)
Lung Neoplasms/radiotherapy , Metronidazole/analogs & derivatives , Radiation-Sensitizing Agents/therapeutic use , Adult , Combined Modality Therapy , Humans , Lung Neoplasms/drug therapy , Lung Neoplasms/surgery , Male , Metronidazole/therapeutic use , Middle AgedSubject(s)
Ileal Diseases/etiology , Ileal Neoplasms/complications , Intestinal Polyps/complications , Intussusception/etiology , Female , Humans , Ileal Diseases/diagnosis , Ileal Diseases/pathology , Ileal Neoplasms/diagnosis , Ileal Neoplasms/pathology , Ileocecal Valve/pathology , Intestinal Polyps/diagnosis , Intestinal Polyps/pathology , Intussusception/diagnosis , Intussusception/pathology , Middle AgedABSTRACT
Eight cases of mesenchymal chondrosarcoma (3 males and 5 females aged 15-65) are described. Morphological examination revealed in all cases biphasal tumor consisting of the chondroid tissue of varying maturity and undifferentiated tissue. Combination and complex treatment was given to 6 patients. In 4 cases, radiotherapy was carried out in combination with chemotherapy and local electromagnetic hyperthermia. Out of 8 patients, seven are still alive and are examined at 4 month - 11 year intervals (average of 39.7 months). One female patient died 12 months after the beginning of treatment. Combined and complex procedures should be recommended for treatment of such patients.
Subject(s)
Bone Neoplasms/diagnosis , Chondrosarcoma/diagnosis , Soft Tissue Neoplasms/diagnosis , Adolescent , Adult , Aged , Bone Neoplasms/pathology , Bone Neoplasms/therapy , Chondrosarcoma/pathology , Chondrosarcoma/therapy , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Neoplasm Metastasis , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/therapyABSTRACT
In the experiments on the C57Bl mice the authors studied the effect of artificial hyperglycemia (AH), amputation of the extremities with tumors as well as combinations of these effects on the intensity of metastatic spreading of carcinoma RL-67 to the lungs. AH did not prove to intensify the process of metastasizing if it was conducted on the 1, 3, 5, 7, 9 and 11th days. The average number of metastases did not differ from that in the control group. AH which was conducted one day before amputation of the extremity with the tumor caused a more significant inhibition of metastasizing than a surgical intervention.
Subject(s)
Blood Glucose/physiology , Neoplasm Metastasis , Neoplasms, Experimental/surgery , Animals , Male , Mice , Mice, Inbred C57BL , Neoplasm Transplantation , Neoplasms, Experimental/pathologyABSTRACT
The authors analysed morphological changes and provided morphological assessment of the parenchyma, stroma, vessels and necrosis in the squamous cell lung carcinoma tissue of 40 patients without preliminary irradiation, 40 patients after gamma-beam therapy and 49 patients after radiotherapy combined with induced hyperglycemia (IH). The total focal dosage was 20 Gy (5 fractions during a week). In 25 patients IH was followed by irradiation and in 24 patients it followed irradiation. Operation was performed on the 7-8th day after therapy was initiated. It was concluded that preoperative gamma-beam therapy followed by IH produced the most noticeable damaging effect on squamous cell lung carcinoma.
Subject(s)
Carcinoma, Squamous Cell/pathology , Glucose/administration & dosage , Lung Neoplasms/pathology , Carcinoma, Squamous Cell/radiotherapy , Combined Modality Therapy , Evaluation Studies as Topic , Gamma Rays/therapeutic use , Humans , Lung/pathology , Lung Neoplasms/radiotherapy , Preoperative Care/methods , Radiotherapy Dosage , Time FactorsSubject(s)
Blood Glucose/analysis , Hot Temperature/therapeutic use , Neoplasms/blood supply , Neoplasms/radiotherapy , Animals , Humans , Mice , Microcirculation , Neoplasms/blood , Neoplasms/therapy , Neoplasms, Experimental/blood , Neoplasms, Experimental/blood supply , Neoplasms, Experimental/radiotherapy , Neoplasms, Experimental/therapy , Radiation ToleranceABSTRACT
The effect of multiple artificial hyperglycemia treatments on metastatic spreading and tumour growth depending on the stage of the tumour development is studied in experiments on mice with transplanted subcutaneous lung cancer LC-67. Intensification of the metastatic spreading and of the primary tumour growth under hyperglycemia treatment of early and advanced diseases is detected. Artificial hyperglycemia does not influence the tumour progress at the terminal stage of the disease.
Subject(s)
Glucose/adverse effects , Lung Neoplasms/drug therapy , Neoplasm Metastasis , Animals , Glucose/therapeutic use , Lung Neoplasms/pathology , MiceABSTRACT
The long-term results of the combined therapy of 284 patients with infiltrative forms of breast cancer were correlated with the manifestations of radiation pathomorphosis in a tumor after preoperative radiation therapy at a single dose of 4 Gy, summary dose of 20 Gy. Surgical intervention was performed in 59% of the patients in the first 3 days after irradiation, in 30% of the patients in 4-9 days, in 11% in 10-20 days. The degree of radiation pathomorphosis was evaluated by the signs of disturbance of the general structure of the tumorous tissue and the structure of some cancer cells. The most significant changes in tumors were recorded 10-20 days after the termination of radiation therapy. An increase in the interval between the termination of irradiation and operation up to 20 days did not influence the long-term results of the combined therapy of patients with breast cancer. No correlation between the degree of radiation pathomorphosis and long-term results of combined therapy was revealed, therefore the qualitative determination of the degree of injury of tissue and cellular elements of a tumor cannot serve as an adequate criterion of efficacy of mean fractional radiation exposure in performing operation in the first 9 days after its completion.
Subject(s)
Breast Neoplasms/therapy , Adult , Breast Neoplasms/pathology , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Middle AgedABSTRACT
Arterial hypotension was found to potentiate antitumor effect of sarcolysin on transplantable sarcoma 45 of rats. Induction of hypotension as modifying factor of chemotherapy of cancer is discussed.
Subject(s)
Hypotension, Controlled , Melphalan/therapeutic use , Sarcoma, Experimental/therapy , Animals , Combined Modality Therapy/methods , Drug Evaluation, Preclinical , Drug Synergism , RatsABSTRACT
The development of bone tumours induced by 3,4-benzpyrene in rats with arterial hypotension and venous congestion was studied. Six months after, osteogenous sarcomas were detected in 36% of animals with normal pressure, in 10%--with arterial hypotension and in 58%--with venous congestion. The differences in the antitumor tissue resistance under chemical blastomogenesis, as well as in cases of transplanted tumours, are supposed to depend on the character of compensatory rearrangements in the microcirculatory bed in response to the intravascular pressure change.