[Cholate-forming function of the liver in patients with chronic alcoholism]. / Kholatoobrazovatel'naia funktsiia pecheni u bol'nykh khronicheskim alkogolizmom.

The level of bile acids was studied in the bile and feces in 119 patients with chronic alcoholism using thin-layer chromatography. The cholate-forming function of the liver was found to increase in patients with short alcohol anamnesis in chronic alcoholism. With advance of the alcohol anamnesis the number of patients with reduced cholate-forming function of the liver increased.

[Pathogenesis of lipid metabolism disorders in patients with atherosclerosis of the vessels of the lower limbs]. / K patogenezu narushenii lipidnogo obmena u bol'nykh s aterosklerozom sosudov nizhnikh konechnostei.

The bile secretory function of the liver in patients with hyperlipoproteinemia complicated by atherosclerosis of the vessels of the lower extremities was studied. It was established, that irrespective of the type of hyperlipoproteinemia in patients, the impairement in the cholate-forming and cholesterin-excreting functions of the liver was present. This aggravated the course of atherosclerosis. The content of common bile acids in patients was, in average, 1-5-fold lower than in normal subjects. The more considerable decrease in the quantity of trihydroxycholanic acids when compared to the dihydroxycholanic ones indicates the inhibition of the processes of synthesis of the bile acids from cholesterin in the hepatocytes in patients with hyperlipoproteinemia.