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1.
Klin Khir (1962) ; (5): 45-7, 1993.
Article in Russian | MEDLINE | ID: mdl-7933864

ABSTRACT

Effect of the complex of antiradical enzymes (superoxide dismutase and catalase in proportion 1:3) was studied on the experimental mode of acute pancreatitis. After thrice repeated administration of a complex of enzymes, antioxidant capacity of the blood serum normalized, activity of the enzymes of antioxidant protection of an organism and that of glucose-6-phosphate dehydrogenase increased, concentration of extra-erythrocytic hemoglobin decreased, contributing to normalization of morphologic structure of the pancreas in 52% of the animals with hemorrhagic and in 70%--with oedematous form pancreatitis. The results obtained are indicative of possible correction of the changes in inflammatory process in the pancreas.


Subject(s)
Antioxidants/therapeutic use , Catalase/therapeutic use , Pancreatitis/drug therapy , Superoxide Dismutase/therapeutic use , Acute Disease , Animals , Antioxidants/pharmacology , Catalase/pharmacology , Glucosephosphate Dehydrogenase/blood , Glucosephosphate Dehydrogenase/drug effects , Hemoglobins/drug effects , Hydroxyl Radical , Lipid Peroxidation/drug effects , Models, Biological , Pancreatitis/metabolism , Rats , Superoxide Dismutase/pharmacology
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