[New calcium-containing product for complex treatment of osteoporosis]. / Novyi kal'tsiisoderzhashchii pishchevoi produkt dlia kompleksnogo lecheniia osteoporoza.

The article presents results of clinical tests of calcium-containing product--dry breakfast "Bodrost"--having in its composition a mineral part of bones of slaughter animals, on patients with menopausal and senil forms of osteoporosis. A chemical composition of the developed product is presented. Results of biochemical tests of blood and urine as well as densitometry of bones of skeleton of patients at the age from 50 to 80 years old are presented. It is established that dry breakfast "Bodrost" can be recommended for complex treatment of osteoporosis.

[X-ray densitometry and biochemical parameters of bone tissue metabolism in patients with vibration disease]. / Rentgenodensitometricheskie i biokhimicheskie pokazateli metabolizma kostnoi tkani u bol'nykh vibratsionnoi bolezn'iu.

To reveal systemic and local osteoporosis, the authors studied biochemical markers of bone metabolism in vibration disease patients. The vibration disease patients appeared to have the most frequent and marked osteoporosis in peripheral bones--hands (in 90% of cases) and forearms (in 66.7%). Prevalence of systemic osteoporosis and osteopenia reached 11.7 and 48.3% in the select respectively. According to biochemical markers, bone reconstruction state was characterized by moderately intensified bone resorption and diminished bone formation.

The role of lysosomes in the pathogenesis of unicameral bone cysts.

Unicameral bone cyst fluid possesses N-acetyl-beta-D-glucosaminidase, beta-glucuronidase, PZ-peptidase, cathepsin D, acid phosphatase, N-acetyl-beta-D galactosaminidase, and beta-galactosidase activities. The activities of lysosomal enzymes in the cyst fluid are, as a rule, higher than in the serum, whereas the total protein content is lower. The content of collagen degradation products in the cyst fluid is higher compared to the serum. In bone cavity wall tissues, the collagen content is decreased. Adenosine 3':5'-cyclic phosphate and cyclic guanosine 3,5'-monophosphate accumulate in the cyst cavity. However, in some cases, there is no correlation among the activities of lysosomal enzymes in the cyst fluid, blood serum, and cyst wall tissues. The ratios of lysosomal enzyme activities in the cyst fluid differ from those in the cyst wall tissues, cultured skin fibroblasts, and blood polymorphonuclear leucocytes. The lack of coincidence of enzymatic spectra of the cyst fluid, wall tissues, and serum is suggestive of the diversity of ways of lysosomal enzyme enter the cyst cavity, i.e., blood, cyst fluid cells, and cyst cavity walls. The cysts with different locations (i.e., active and latent cysts) have similar lysosomal lytic potentials. The presence in the cyst cavity of extracellular lysosomal enzymes and collagen degradation products testifies to the permanent corrosion of the cyst cavity walls from the inside as well as to the increase in the osmotic pressure of the cyst fluid. Lysosome destruction should be regarded as an important pathogenetic factor that requires surgical or pharmacologic correction or both in the course of bone cyst management.

[Relation of the outcome of disk epiphysectomy in dysplastic scoliosis and the biochemical composition of the vertebral body]. / Zavisimost' iskhoda disképifizéktomii pri displasticheskom skolioze ot biokhimicheskogo sostava tela pozvonka.

Pronounced changes in the content of collagen, non-collagen proteins and the activity of a number of lysosomic enzymes have been established in the bone tissue of the vertebral bodies obtained on diskepiphysectomy in the patients with dysplastic scoliosis. Numerous correlation links between the metabolic parameters and the spinal deformation a year after diskepiphysectomy have been determined.

[Collagen metabolism in Dupuytren's contracture]. / Obmen kollagena pri kontrakture Diupiuitrena.

Impairments in collagen metabolism were observed in patients with Dupuytren's contracture. These impairments were manifested as an increased excretion of hydroxyproline with urine and a decrease in content of the amino acid in tissues of aponeurosis palmaris of the patients. The alterations correlated with the damage caused by contracture. Increased catabolism of collagen appears to be the main reason of the metabolic impairments observed in Dupuytren's contracture, considering the opposite direction of changes in hydroxyproline content in urine and in aponeurosis palmaris of the patients. Impairments in collagen metabolism were of considerable importance in Dupuytren's contracture as demonstrated by the correlation between biochemical alterations and severity of the pathology. The Dupuytren's contracture might be considered as a disease affecting the connective tissue.

[Metabolism of collagen in infectious nonspecific (rheumatoid) polyarthritis]. / Metabolizm kollagena pri infektsionnom nespetsificheskom (revmatoidnom) poliartrite

Distinct impairments in collagen metabolism were observed in infectious (rheumatoid) polyarthritis. The impairements were manifested as increased excretion of hydroxyproline with urine and increased content of protein bound hydroxyproline in blood plasma and synovial fluid; the impairements increased with an increased in severity and abundance of pathological process in connective tissue. After successful treatment of patients (surgical operation, combined with complex antirheumatic treatment) content of the collagen metabolites was decreased in biological fluids; this decrease was not observed if the inflammatory process in the connective tissue was present.

[Collagen metabolism in patients with bone system tumors]. / Issledovanie obmena kollagena u bol'nykh s opukholiami kostnoi sistemy.

In patients with bone system tumours, disturbances in collagen metabolism are manifested by enhanced excretion of hydroxyproline with urine while the content of collagen-like protein in blood plasma remains normal. Excretion of hydroxyproline with urine in patients with benign tumours is enhanced to a lesser extent than in patients with malignant tumours of the bone-cartilage system. In patients with benign tumours of the skeleton, greatest changes in the excretion of hydroxyproline with urine were found in the case of osteoblastoclastoma. The most significant changes in patients with malignant tumours of bone system tumours were observed during osteogenic and especially paraosteal carcinoma. After removal of the tumour in postoperative period without complications, excretion of hydroxyproline with urine is normalized but in the case of metastasis, recidivation or persisting growth of tumour, hydroxyprolinuria is maintained at a high level.