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J Antibiot (Tokyo) ; 40(12): 1698-706, 1987 Dec.
Article in English | MEDLINE | ID: mdl-2828297

ABSTRACT

A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.


Subject(s)
Anti-Bacterial Agents/isolation & purification , Streptomyces/analysis , Streptothricins/isolation & purification , Aminoglycosides , Anti-Bacterial Agents/pharmacology , Chemical Phenomena , Chemistry, Physical , Fermentation , Gas Chromatography-Mass Spectrometry , Isomerism , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Soil Microbiology , Spectrophotometry, Infrared , Streptothricins/pharmacology
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