[Prognostic evaluation of patients with arteriosclerosis obliterans]. / Prognosztikai vizsgálatok arteriosclerosis obliteransos betegekben.

The natural course of 365 random patients with peripheral arterial obliterative disease was followed up on an average 8 years. In 36% of the patients worsening of angiological condition has been shown. The state of the other patients was unchanged (55%) or improved (9%). During the observation period 87 angiological surgeries and amputation of 41 lower limbs were performed, most of them in 1-2 years after onset of the disease. At follow up in 151 cases myocardial infarction and in 72 cases stroke occurred; the incidence of both diseases was characterized by a cluster like accumulation in 1-3 years before or after onset of the disease. The deterioration of the angiological condition of the patients was related to smoking (mainly heavy smoking), diabetes mellitus and-even more markedly--to the combinations of different risk factors including smoking. The pathological levels of haemorheological factors also showed significant connection with the severity of the disease. In the prospective 6 year period of the study 147 patients (40%) died. This mortality was twice that of the general population matched for age and sex. Information about the cause of death could be collected in 128 cases (87%), among them 51 (40%) died of vascular diseases (peripheral arterial obliterative disease, myocardial infarction, stroke).

Several years observations with Mydocalm muscle relaxant in locomotor disease patients.

Two therapeutic methods were compared on locomotor disease patients; the currently used anti-inflammatory complex therapy and the same therapy complemented with Mydocalm. On the basis of the changes of pain indices and motion indices chosen as parameters it could be concluded that Mydocalm is a valuable adjuvant, especially in improving locomotor functions, and it promotes the improvement of the general condition of the patients and the performance of their daily activities by relieving muscular hypertonia and contractures.