ABSTRACT
Objective: The aim of this study was to determine current and previous SARS-COV-2 infection, and describe risk factors associated with seropositivity, among HCWs and hospital staff between June and October of 2020. Methodology: Data from the day of enrollment for a prospective cohort study were analyzed to determine point prevalence and seroprevalence of SARS-CoV-2 infection in HCWs and hospital staff of a university hospital in Colombia. Respiratory samples were collected to perform RT-PCR tests, along with blood samples to measure SARS-CoV-2 IgM and IgG antibodies. Data on nosocomial and community risk factors for infection were also collected and analyzed. Findings: 420 HCWs and hospital staff members were included. The seroprevalence at baseline was 23.2%, of which 10.7% had only IgM antibodies, 0.7% had IgG, and 11.7% had IgM and IgG. The prevalence of acute SARS-CoV-2 infection was 1.9%. Being a nurse assistant was significantly associated with seropositivity when compared with all other job duties (PR 2.39, 95% CI 1.27-3.65, p = 0.01). Conclusions: Overall SARS-CoV-2 prevalence was 1.9% and seroprevalence was 23.15%. Nurse assistants, medical doctors or students, and laboratory workers had a higher possibility of being SARS-CoV-2 seropositive.
ABSTRACT
PURPOSE: Practice guidelines suggest that patients with obstructive sleep apnea (OSA) should be monitored postoperatively to reduce adverse events. This study evaluated outcomes following ambulatory surgery in patients who had previously undergone polysomnography (PSG), and compared unplanned admissions in patients diagnosed with OSA with those in patients without OSA. METHODS: A historical cohort study (July 2003 to March 2009) was conducted using administrative data and supplemented by selective chart review. Patients undergoing ambulatory surgery at the Ottawa Hospital who had a previously documented PSG were identified. The PSG reports were reviewed, and the presence and severity of OSA was determined. Unplanned admissions to hospital within seven days of surgery were identified using administrative data. Using a nested case-control design, three charts were randomly selected for each patient admitted for a focussed health records review. Event rates in patients with OSA and treated with continuous airway pressure were compared with event rates in patients without OSA. An exploratory multivariable analysis was conducted to identify predictors of admission. RESULTS: There were 77,809 ambulatory surgical procedures in the period studied. A PSG test could be analyzed in 1,547 patients, and OSA was diagnosed in 674 (44%) of those analyzed. The rate of unplanned admission was 7.0% (95% confidence interval [CI] 5.1 to 8.9) in OSA patients compared with 5.6% (95% CI 4.1 to 7.1) in patients without OSA (odds ratio 1.26; 95% CI 0.83 to 1.91; P = 0.246). Median [interquartile range; IQR] hospital length of stay was 7 hr [IQR 5, 8] with OSA and 6 hr [IQR 5, 8] without OSA (P = 0.058). Severity of OSA was not associated with unplanned admission. CONCLUSIONS: We did not identify a clinically important increased rate of unplanned admission associated with a prior diagnosis of OSA.
