Validación del perfil de estrés de nowack en estudiantes universitarios mexicanos / Validation of nowack's stress profile in mexican university students

RESUMEN Objetivos a. Adaptar y validar el "Perfil de Estrés" para la población mexicana; b. Determinar la proporción de varianza que el instrumento es capaz de explicar de los datos originales a partir de un modelo factorial; c. Agrupar las variables en los factores en donde saturan con mayor claridad; d. Evaluar la validez de contenido del instrumento, y; e. Evaluar la consistencia interna del instrumento. Método La muestra de validación estuvo compuesta por 883 participantes, 58.3% mujeres y 41.7% hombres, con edades entre 15 y 76 años (M=21.40, DE=10.02). Para verificar la validez psicométrica de la escala se llevaron a cabo el procedimiento propuesto por Reyes-Lagunes y García-Barragán (2008), el cual consta de los siguientes pasos: a. Frecuencia incluyendo sesgo para la selección de reactivos; b. Discriminación de reactivos para grupos extremos con base en el cual se eliminarán los que no cumplen con el requisito; c. Confiabilidad interna, y; d. Validez. Resultados El "Perfil de Estrés" presenta características psicométricas adecuadas para la población mexicana (alfa de Cronbach de 0.65 a 0.93). Conclusión El "Perfil de estrés" fue adaptado y validado para la cultura mexicana. Se considera que se trata de un instrumento útil para estudios que se propongan evaluar los factores asociados con el estrés en general, incluyendo los hábitos de salud, los estilos de afrontamiento y bienestar psicológico.(AU)

ABSTRACT Objectives This work sees to a) adapt and validate the "Stress profile" for the Mexican population, b) determine the proportion of variance that the instrument is able to explain based on the original data of a factorial model, c) group the variables into factors where they saturate most clearly, d) evaluate the validity of the content of the instrument, and e) evaluate the internal consistency of the instrument. Methods The validation sample consisted of 883 participants, 58.3% women and 41.7% men, aged between 15 and 76 years (M=21.40, SD=10.02). To verify the psychometric validity of the scale, the procedure proposed by Reyes-Lagunes and García-Barragán (2008) was used. It consists of the following steps: a) frequency, including bias for the selection of reagents; b) discrimination of reagents for extreme groups, having in mind that those that do not comply with the requirement will be eliminated; c) internal reliability; and d) validity. Results The "Stress Profile" has adequate psychometric characteristics for the Mexican population (Cronbach's alpha of 0.65 to 0.93). Conclusion The "Stress Profile" was adapted and validated for the Mexican population. This is a useful tool for studies that aim to evaluate the factors associated with stress in general, including health habits, coping styles and psychological well-being.(AU)

[Validation of Nowack's Stress Profile in Mexican university students]. / Validación del Perfil de Estrés de Nowack en estudiantes universitarios mexicanos.

OBJECTIVES: This work sees to a) adapt and validate the "Stress profile" for the Mexican population, b) determine the proportion of variance that the instrument is able to explain based on the original data of a factorial model, c) group the variables into factors where they saturate most clearly, d) evaluate the validity of the content of the instrument, and e) evaluate the internal consistency of the instrument. METHODS: The validation sample consisted of 883 participants, 58.3% women and 41.7% men, aged between 15 and 76 years (M=21.40, SD=10.02). To verify the psychometric validity of the scale, the procedure proposed by Reyes-Lagunes and García-Barragán (2008) was used. It consists of the following steps: a) frequency, including bias for the selection of reagents; b) discrimination of reagents for extreme groups, having in mind that those that do not comply with the requirement will be eliminated; c) internal reliability; and d) validity. RESULTS: The "Stress Profile" has adequate psychometric characteristics for the Mexican population (Cronbach's alpha of 0.65 to 0.93). CONCLUSION: The "Stress Profile" was adapted and validated for the Mexican population. This is a useful tool for studies that aim to evaluate the factors associated with stress in general, including health habits, coping styles and psychological well-being.

OBJETIVOS: a. Adaptar y validar el "Perfil de Estrés" para la población mexicana; b. Determinar la proporción de varianza que el instrumento es capaz de explicar de los datos originales a partir de un modelo factorial; c. Agrupar las variables en los factores en donde saturan con mayor claridad; d. Evaluar la validez de contenido del instrumento, y; e. Evaluar la consistencia interna del instrumento. MÉTODO: La muestra de validación estuvo compuesta por 883 participantes, 58.3% mujeres y 41.7% hombres, con edades entre 15 y 76 años (M=21.40, DE=10.02). Para verificar la validez psicométrica de la escala se llevaron a cabo el procedimiento propuesto por Reyes-Lagunes y García-Barragán (2008), el cual consta de los siguientes pasos: a. Frecuencia incluyendo sesgo para la selección de reactivos; b. Discriminación de reactivos para grupos extremos con base en el cual se eliminarán los que no cumplen con el requisito; c. Confiabilidad interna, y; d. Validez. RESULTADOS: El "Perfil de Estrés" presenta características psicométricas adecuadas para la población mexicana (alfa de Cronbach de 0.65 a 0.93). CONCLUSIÓN: El "Perfil de estrés" fue adaptado y validado para la cultura mexicana. Se considera que se trata de un instrumento útil para estudios que se propongan evaluar los factores asociados con el estrés en general, incluyendo los hábitos de salud, los estilos de afrontamiento y bienestar psicológico.

Pathways into psychopathology: Modeling the effects of trait emotional intelligence, mindfulness, and irrational beliefs in a clinical sample.

We investigated possible pathways into mental illness via the combined effects of trait emotional intelligence (trait EI), mindfulness, and irrational beliefs. The sample comprised 121 psychiatric outpatients (64.5% males, mean age = 38.8 years) with a variety of formal clinical diagnoses. Psychopathology was operationalized by means of 3 distinct indicators from the Millon Clinical Multi-Axial Inventory (mild pathology, severe pathology, and clinical symptomatology). A structural equation model confirmed significant direct trait EI and mindfulness effects on irrational beliefs and psychopathology. Trait EI also had a significant indirect effect on psychopathology via mindfulness. Together, the 3 constructs accounted for 44% of the variance in psychopathology. A series of hierarchical regressions demonstrated that trait EI is a stronger predictor of psychopathology than mindfulness and irrational beliefs combined. We conclude that the identified pathways can provide the basis for the development of safe and effective responses to the ongoing mental health and overmedication crises. KEY PRACTITIONERS MESSAGES: Self-perception constructs concerning one's beliefs about oneself have a major impact on the likelihood of developing psychopathological symptoms. Emotional perceptions captured by trait emotional intelligence were stronger predictors of psychopathology than either or both mindfulness and irrational beliefs in a clinical sample of adults. If the seed factors of psychopathology are mainly psychological, rather than mainly biological, and given that psychological constructs, like trait emotional intelligence, mindfulness, and irrational beliefs, are amenable to training and optimization, the findings herein provide the impetus for a much needed shift of emphasis from pharmacological to psychological treatments.

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

Drug discovery for malaria has been transformed in the last 5 years by the discovery of many new lead compounds identified by phenotypic screening. The process of developing these compounds as drug leads and studying the cellular responses they induce is revealing new targets that regulate key processes in the Plasmodium parasites that cause malaria. We disclose herein that the clinical candidate (+)-SJ733 acts upon one of these targets, ATP4. ATP4 is thought to be a cation-transporting ATPase responsible for maintaining low intracellular Na(+) levels in the parasite. Treatment of parasitized erythrocytes with (+)-SJ733 in vitro caused a rapid perturbation of Na(+) homeostasis in the parasite. This perturbation was followed by profound physical changes in the infected cells, including increased membrane rigidity and externalization of phosphatidylserine, consistent with eryptosis (erythrocyte suicide) or senescence. These changes are proposed to underpin the rapid (+)-SJ733-induced clearance of parasites seen in vivo. Plasmodium falciparum ATPase 4 (pfatp4) mutations that confer resistance to (+)-SJ733 carry a high fitness cost. The speed with which (+)-SJ733 kills parasites and the high fitness cost associated with resistance-conferring mutations appear to slow and suppress the selection of highly drug-resistant mutants in vivo. Together, our data suggest that inhibitors of PfATP4 have highly attractive features for fast-acting antimalarials to be used in the global eradication campaign.