ABSTRACT
Pilomatrixial carcinoma is the malignant variety of pilomatrixoma. It is a malignant lesion, locally aggressive that can reappear, specially if not completely removed. Scanty are the number of cases listed in the literature (2). Although metastases are uncommon one or twice references can be found in the writings (1). We report 2 cases of pilomatrixial carcinoma located in the middle canthal and malar zones, which were treated surgically: excision of the tumor and reconstruction by means of a local rotation flap.
Subject(s)
Hair Diseases/pathology , Pilomatrixoma/pathology , Skin Neoplasms/pathology , Aged , Aged, 80 and over , Diagnosis, Differential , Face , Female , Hair Diseases/surgery , Humans , Male , Pilomatrixoma/surgery , Skin Neoplasms/surgeryABSTRACT
OBJECTIVE: To determine the prognostic value of p53 protein expression in relation to progression of superficial bladder cancer. METHODS: A retrospective study was conducted in which p53 protein was determined in TUR fragments of 18 patients with superficial transitional cell carcinoma of the bladder with no evidence of tumor progression in the last 6 years and in 13 patients with superficial tumors that had become invasive. DO-7 monoclonal antibody was utilized (+if stained nuclei were more than 25%). RESULTS: Expression of p53 protein was found in 9 patients (50%) with bladder tumors that had not progressed and in 6 patients (46.1%) with bladder tumors that had become invasive (p = 0.83). CONCLUSION: Determination of p53 protein was not related with cancer progression in this series.
Subject(s)
Carcinoma, Transitional Cell/metabolism , Gene Expression Regulation, Neoplastic , Tumor Suppressor Protein p53/biosynthesis , Urinary Bladder Neoplasms/metabolism , Aged , Female , Humans , Male , Middle Aged , Retrospective StudiesABSTRACT
Carcinosarcoma of the salivary gland is a rare lesion, estimated at 0.2% of malignant salivary gland tumors [1, 2]. The present article describes a case occurring in a 54-year-old man with a submandibular mass in the right neck. Histologically, this lesion was a carcinosarcoma which involves the submandibular and the sublingual glands. Its stromal component was a chondrosarcoma and the epithelial one was an undifferentiated carcinoma in the whole tumor, with areas of adenoid cystic carcinoma in the sublingual gland. To our knowledge, we have not found any previously reported carcinosarcoma involving the sublingual gland.
Subject(s)
Carcinosarcoma/pathology , Sublingual Gland Neoplasms/pathology , Submandibular Gland Neoplasms/pathology , Carcinoma/pathology , Carcinoma/secondary , Carcinoma, Adenoid Cystic/pathology , Chondrosarcoma/pathology , Diagnosis, Differential , Follow-Up Studies , Humans , Lymphatic Metastasis/pathology , Male , Middle Aged , Neoplasm Invasiveness , Neoplasms, Multiple Primary/pathologyABSTRACT
Atypical fibroxanthoma has a wide spectrum of histological appearances. A variant recently described is atypical fibroxanthoma with osteoclast-like giant cells. One case of this rare tumour is described. The tumour arose on the forehead of an 87-year-old woman in the form of a subepidermal nodule. The lesion was incompletely excised and recurred 6 months later without showing any characteristics of aggression. Six months after the second operation the patient was well and showed no signs of tumour recurrence. Immunohistological findings showed a "fibrohistiocytic" profile and were similar to those observed in other lesions rich in osteoclast-like giant cells. Flow cytometry revealed the diploid nature of the primary and the recurrent tumour. Atypical fibroxanthoma with osteoclast-like giant cells is a new variant of atypical fibroxanthoma that must be recognized by pathologists, since it can be confused with other benign and malignant tumours with a high proportion of multinucleate osteoclast-like giant cells.
