Subject(s)
Hypersensitivity , Iodine , Nuclear Medicine , Contrast Media , Humans , Radionuclide ImagingABSTRACT
Thin-layer radiochromatography is used for carrying out radiochemical purity control of gamma-emitter radiopharmaceuticals by using thin-layer radiochromatography scanners. It has been developed and implemented a simple method for validating the proper functioning of these instruments. This method helps to ensure accurate results in the radiochemical purity controls of gamma-emitter radiopharmaceuticals.
Subject(s)
Chromatography, Thin Layer/methods , Chromatography, Thin Layer/standards , Drug Contamination/prevention & control , Radiopharmaceuticals/analysis , Radiopharmaceuticals/chemistry , Quality Control , Radiochemistry , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
This work describes the development of a software application for reporting patient radiation dosimetry following radiopharmaceutical administration. The resulting report may be included within the patient's medical records. The application was developed in the Visual Basic programming language. The dosimetric calculations are based on the values given by the International Commission on Radiological Protection (ICRP). The software is available in both Spanish and English and can be downloaded at no cost from www.radiopharmacy.net.
Subject(s)
Documentation/methods , Electronic Health Records/organization & administration , Information Storage and Retrieval/methods , Radiometry/classification , Radiopharmaceuticals/classification , Software , Internet , User-Computer InterfaceABSTRACT
In the last years, there has been a growing recognition of the importance of blood volume abnormalities in the pathophysiology of several conditions and, consequently, a growing interest of accurate and rapid volume status assessment. Accordingly, there has been a surge of interest in blood volume analysis by radioisotopic dilution technique. However, there are still some controversies about this technique, such as the use of the f-cell ratio, the errors associated with the method and the reference values. This review aims to revise and discuss the theoretical and methodological aspects of this technique and also to discuss their controversies. Furthermore, it is questioned whether red cell volume or plasma volume can be accurately estimated once the other quantity has been measured or should red cell volume and plasma volume be directly measured. As a conclusion, blood volume analysis by radioisotopic dilution technique is still valid and very useful.
Subject(s)
Blood Volume , Radioisotope Dilution Technique , Adult , Anticoagulants , Erythrocyte Volume , Female , Hematocrit , Hemolysis , Humans , Indicator Dilution Techniques , Male , Patient Positioning , Plasma Volume , Radioisotope Dilution Technique/standards , Radioisotope Dilution Technique/statistics & numerical data , Reference ValuesABSTRACT
UNLABELLED: Our objective was to develop a software application that allows us to easily manage a portable database of information on radiopharmaceutical interactions with drugs or other agents and on radiopharmaceutical adverse effects. METHODS: The application was developed and compiled with a commercially available data management system and programming language. All data entered into the database came from the scientific literature and were accompanied by their bibliographic references. RESULTS: We developed the database, which we have called Datinrad. To date, it contains 275 drug interactions and 44 records of adverse reactions to radiopharmaceuticals. CONCLUSION: Datinrad contains all the information published to date on drug-radiopharmaceutical interactions and adverse effects of radiopharmaceuticals and allows users to introduce new data from future publications. The collection of these data and their easy availability to all nuclear medicine personnel will be useful in the recognition of a possible adverse reaction or drug interaction that may alter the radiopharmaceutical biodistribution and lead to a misdiagnosis. This open-access database application is available free of charge in both English and Spanish at www.radiopharmacy.net.
Subject(s)
Databases, Pharmaceutical , Drug Interactions , Drug-Related Side Effects and Adverse Reactions , Radiopharmaceuticals/adverse effects , Information Storage and Retrieval , Nuclear Medicine , User-Computer InterfaceABSTRACT
A database software application for comprehensive management and traceability of hospital radiopharmacies has been developed and implemented. This software is a customizable shareware called Radiolab, which provides an immediate and complete traceability of all preparations, controls and radiopharmaceuticals, as well as a great help in the management of reports, orders, stock and radioactive waste. Available by now in five languages (English, Spanish, French, Portuguese and Italian) this software and its manual can be downloaded from the Internet at www.radiopharmacy.net.
