ABSTRACT
OBJECTIVE: To define perinatal factors associated with early-onset neonatal sepsis. STUDY DESIGN: Maternal and neonatal variables were analysed retrospectively in 343 infants born before 35 weeks using univariate and multivariate statistical analysis. RESULTS: Logistic regression analysis identified risk factors for probable neonatal sepsis: gestational age at delivery (odds ratio 0.9, 95% confidence interval (CI) 0.91-0.96), premature rupture of the membranes (odds ratio 2.9, 95% CI 1.004-8.56), Apgar score after 1 min (odds ratio 0.7, 95% CI 0.53-0.96), and histological chorioamnionitis and/or funisitis (odds ratio 4.1, 95% CI 1.36-12.12). There was a strong association between probable sepsis and intracranial haemorrhage of the infant (odds ratio 4.3, 95% CI 1.07-17.40). Funisitis had a high specificity (91%) and positive predictive value (82%) for the detection of neonatal sepsis < or =32 weeks. CONCLUSIONS: Independent obstetrical risk factors for early-onset neonatal sepsis in premature infants may help to identify newborns who benefit from maternal antibiotic prophylaxis before birth. The histological examination of the umbilical cord can be used as an additional diagnostic test to detect newborns at risk of infection.
Subject(s)
Infant, Premature, Diseases/etiology , Sepsis/etiology , Antibiotic Prophylaxis , Chorioamnionitis/complications , Enterobacter/isolation & purification , Escherichia coli/isolation & purification , Female , Fetal Membranes, Premature Rupture/complications , Gestational Age , Humans , Infant, Newborn , Infant, Premature , Infant, Premature, Diseases/microbiology , Logistic Models , Odds Ratio , Pregnancy , Pseudomonas aeruginosa/isolation & purification , Retrospective Studies , Risk Factors , Sepsis/microbiology , Sepsis/pathology , Sepsis/prevention & control , Staphylococcus aureus/isolation & purification , Staphylococcus epidermidis/isolation & purification , Streptococcus agalactiae/isolation & purification , Umbilical Cord/pathologySubject(s)
Pulpitis/therapy , Zinc Oxide-Eugenol Cement/therapeutic use , Adolescent , Adult , Humans , Middle Aged , Pulpectomy , Pulpitis/diagnosis , PulpotomySubject(s)
Administration, Topical , Anti-Inflammatory Agents/therapeutic use , Dexamethasone/therapeutic use , Formaldehyde/therapeutic use , Hydrocortisone , Root Canal Filling Materials/therapeutic use , Thymol/analogs & derivatives , Adult , Dental Pulp Cavity/anatomy & histology , Drug Combinations/therapeutic use , Drug Evaluation , Humans , Root Canal Therapy , Thymol/therapeutic useSubject(s)
Mouth Diseases/etiology , Sulfur/adverse effects , DMF Index , Environmental Exposure , Humans , Occupational Dentistry , Oral Hygiene Index , PolandABSTRACT
The purpose of the study was to investigate the clinical state of the mucosa of the oral cavity, the paradontium and dentition in workers of Siarkopol in Gdansk. Stomatologic examinations were performed in 105 workers who had been exposed to the action of sulphur dust. The subjects examined, showed inflammatory changes in the mucosa of the oral cavity (72,4%) and nontypical erosion of tooth enamel (11,4%). 74,28% of the subjects examined showed changes in the paradontium. The oral cavity of all Siarkopol workers was found to be in a poor state of hygiene.
