Prenatal diagnosis of aortic atresia by colour Doppler flow mapping.

A case of aortic atresia with insufficiency of mitral valve diagnosed prenatally at 33 weeks of gestation is presented. An accurate diagnosis of this fetal cardiovascular malformation was possible by application of Doppler colour flow mapping, which demonstrated (a) the absence of forward flow in the hypoplastic ascending aorta, (b) reverse flow of blood from the ductus arteriosus into the severely hypoplastic ascending aorta in the late systole, (c) pansystolic mitral valve regurgitation, and (d) absent flow across the foramen ovale as a result of premature closure of the foramen ovale.

The fetal phenotype of the 18p-syndrome. Report of a male fetus at twenty-one weeks.

Morphological and cytogenetic findings in a male fetus at 21 weeks gestation after prenatally detected monosomy 18p are reported. The fetus displayed dysmorphic features resembling the 18p-syndrome, such as decreased head circumference, slightly receding forehead, hypertelorism, epicanthus, horizontal palpebral fissures, depressed nasal bridge, long philtrum, carp mouth, irregular crenated maxillar alveolar ridge, retrognathia, lowset dysplastic ears with posterior rotation, edema of neck, hands and feet respectively, fingers with drop-shaped tips, short first toes with dysplastic nails, hypoplastic male external genitalia. After termination of the pregnancy, biopsies from different fetal organs as well as from the placenta were taken and set up for long term cell cultures. The metaphases of fetal organs all showed the karyotype 46,XY,18p-. A fetal blood culture failed to grow. Unexpectedly, the metaphases of the placenta showed the mosaic karyotype 46,XY/46,XY,18p-/46,XY,18p+.

Mosaicism of isochromosome 18p. Cytogenetic and morphological findings in a male fetus at 21 weeks.

The first case of isochromosome 18p as a mosaic in a male fetus diagnosed by amniocentesis is reported. After termination of the pregnancy at 21 weeks gestation biopsies from different fetal organs as well as from the placenta were taken and set up for long term cell cultures. The distribution of the normal and abnormal cell-line in fetal organs was unequal. Unexpectedly the metaphases in the placenta and the lymphocyte culture all showed a normal karyotype. The tetrasomy 18p is associated with a uniform phenotype, even in fetal life, characterized by a small head with protuberant occiput, low-set ears with posterior rotation, epicanthic fold, sharp pinched nose, convex and poorly formed philtrum, high-arched palate, retrognathia, flexion contractures of fingers, short and broad hallux, hypoplastic penis, angulation of clavicles and mild scoliosis. The propositus showed no growth retardation.

[Solitary polypoid cavernous hemangioma in the jejunum]. / Solitäres polypöses kavernöses Hämangiom im Jejunum.

Hemangiomas of the small intestine are rare. A case report is given of a 77 year old patient with upper gastrointestinal bleeding. Selective arteriography of the art. mesenterica superior revealed a convoluted mass of 1 cm diameter in the arciform arterial segment of a jejunal artery. The jejunal loop affected was removed and end-to-end anastomosis of the small intestine was performed; on histological examination a solitary polypoid cavernous hemangioma with a diameter of 6 mm was found. The patient is doing well 2 1/4 years after surgery.

[Outpatient coronary groups. 1st experiences with high-risk infarct patients after a year's model experiment]. / Ambulante Koronar-Gruppen Erste Erfahrungen mit minderbelastbaren (High risk-)Infarkt-Patienten nach einjährigem Modellversuch.

One year's experience with patients after myocardial infarction with low physical capacity (high risk-patients) and their participation in coronary clubs. After satisfactory results have been recorded with coronary training-groups at Hamburg first results can be reported from a trial with a coronary exercising-group at the patient's community. Patients after myocardial infarction with low physical capacity (high risk-patients) have participated regularly in coronary club meetings. One year's observation with medical controls showed no hazards from special adapted exercises combined with health education. Cardiac complications did not occur. The exercise program aims on increasing coordination and flexibility; general aerobic endurance is not to be improved. Thus a better and more economical functioning of the cardiovascular system is reached; life quality is improved. Further propagation of the coronary exercising-program is recommended if the described precautions are observed. This way many coronary patients could benefit also from long-time participation in comprehensive care in coronary clubs, which were up to now excluded from coronary training groups because of high risk.

[3H-thymidine-paper strip-counting of in vitro lymphocyte transformation. II. Specific antigens in the whole blood assay (author's transl)]. / Die 3H-Thymidin-Papierplättchen-Modifikation des lymphozytentransfomationstestes (LTT). II. Vollblut-LTT mit Einsatz spezifischer Antigene.

Erythrocytes did not influence the harvesting procedure or the paper strip counting method in a liquid scintillation counter using the whole blood assay of lymphocyte transformation test. The leucocyte-erythrocyte-ratio influences the blastogenesis in vitro. Only 1--2 ml of peripheral blood are necessary to proof lymphocyte reactivity to mitogens or antigens. The storage of the blood is possible over a period of 24 hours (4 degrees C) if the absolute lymphocytes count remains constant.

[Cavernous hemangioma of the umbilical cord]. / Kavernöses Hämangiom der Nabelschnur

A case of a cavernous haemangioma of the umbilical cord not far from the stillborn infant of 30 weeks gestation is reported. Autopsy revealed no intrauterine growth retardation, malformation and fetopathia. The placenta shows disorders of vasculartiy.

[Contribution to the subacute necrotic myelitis (Foix-Alajouanine) (author's transl)]. / Beitrag zur angiodysgenetischen nekrotisierenden Myelopathie (Foix-Alajouanine)

A case of a 54 years old man with an acute lumbalgia in result of heavy labour is described. With in 7 years he developed a progressive paralysis of the upper and lower motor neuron type and an insensibility of the inferior extremities. The protein content of the cerebrospinal fluid was increased. The cells were insignificantly increased in number. No tumour was detected. The man died at the age of 62 on intoxication by infected decubitus and focal pneumonia. Autopsy revealed subacute necrotic myelitis (Foix-Alajouanine) with enlarged, varicose, and thickened extramedullary veins of the sacral, lumbal, and lower thoracic spinal cord, which was soft and diminished in size. In the grey and white matter of the cord, there were found more numerous and more prominent vessels like an angioma capillare et venosum; complete and incomplete necrosis was observed, partially with plasmatic infiltration. Some nerve cells were still present. Nerve fibres without myelin mantle were found in the spinal cord as well as in the spinal roots. The authors support the suggestion that the subacute necrotic myelitis results from a dysgenesis of the spinal venous vessels.