1.
Neuropediatrics
; 38(3): 151-3, 2007 Jun.
Article
in English
| MEDLINE
| ID: mdl-17985266
ABSTRACT
Growth factors have been implicated in the pathogenesis of autism. We have investigated daily urinary excretion of insulin-like growth factor-1 (IGF-1), epidermal growth factor, and insulin-like growth factor binding protein-3 in autistic children (n=34, age 2-5 years) and age-matched control children (n=29). The mean urinary IGF-1 level was lower in the autism group than the control group (p=0.03). Height was normal. These findings suggest altered IGF-1 metabolism in young autistic children. The cause-effect relationship should be examined by longitudinal studies and insulin-like growth factor provocation tests.
Subject(s)
Autistic Disorder/urine , Epidermal Growth Factor/urine , Insulin-Like Growth Factor I/urine , Case-Control Studies , Child, Preschool , Female , Humans , Male
2.
Eur Child Adolesc Psychiatry
; 8(2): 154-6, 1999 Jun.
Article
in English
| MEDLINE
| ID: mdl-10435465