Subject(s)
Adenocarcinoma/epidemiology , Bronchial Neoplasms/epidemiology , Carcinoma, Small Cell/epidemiology , Tracheal Neoplasms/epidemiology , Adenocarcinoma/diagnosis , Adult , Aged , Bronchial Neoplasms/diagnosis , Bronchoscopy , Carcinoma, Small Cell/diagnosis , Female , Humans , Male , Middle Aged , Tracheal Neoplasms/diagnosis , TurkeySubject(s)
Lung/pathology , Lymph Nodes/pathology , Sarcoidosis/pathology , Adolescent , Adult , Aged , Biopsy , Bronchoscopy , Female , Fiber Optic Technology , Humans , Male , Middle AgedABSTRACT
The incidence of the location within the bronchi related to the cell types was investigated with the flexible fiberoptic bronchoscope in 355 cases of lung carcinoma. In 5 patients carcinoma was situated only in the trachea. In the other 350 cases the cell types other than adenocarcinoma were found to show different locations following their cell type. Epidermoid carcinoma was found more frequently in the two upper lobes (p less than 0.001), while small cell carcinomas showed predilection for the main bronchus on the right side, and the upper lobe in the left (p less than 0.001). No difference could be found between the upper, lower lobes and main bronchi for adenocarcinoma. It was also observed that large cell carcinomas were situated more often in the right upper lobe. The most important finding in this investigation was that, apart from adenocarcinoma, the other types were located mainly in the upper lobes, and much less frequently in the lower lobes. The predilection of localization of epidermoid and small cell carcinomas in the upper lobes suggests a possible relationship to tobacco smoke inhalation as these regions have been shown to be more affected by the smoke.
Subject(s)
Adenocarcinoma/epidemiology , Bronchial Neoplasms/epidemiology , Carcinoma, Small Cell/epidemiology , Carcinoma, Squamous Cell/epidemiology , Carcinoma/epidemiology , Lung Neoplasms/epidemiology , Tracheal Neoplasms/epidemiology , Adenocarcinoma/pathology , Adult , Aged , Bronchial Neoplasms/pathology , Bronchoscopy , Carcinoma/pathology , Carcinoma, Small Cell/pathology , Carcinoma, Squamous Cell/pathology , Female , Humans , Lung Neoplasms/pathology , Male , Middle Aged , Tracheal Neoplasms/pathologySubject(s)
Immunoglobulins/analysis , Leprosy/immunology , alpha 1-Antitrypsin/analysis , Female , Humans , Leprosy/blood , Male , Middle AgedABSTRACT
IgG, IgA, and IgM immunoglobulins and alpha-1-antitrypsin globulin in sera from 30 patients with lepromatous leprosy were determined and compared with 30 age- and sex-matched healthy controls. Mean levels of IgG, IgM, IgA, and alpha-1-antitrypsin were significantly elevated in the sera of lepromatous leprosy patients in comparison with levels found in normal subjects. Statistical analysis of the relationships between levels of alpha-1-antitrypsin and immunoglobulins in the sera of lepromatous leprosy patients and controls revealed no correlation. It is therefore concluded that factors responsible for concentrations of immunoglobulins and alpha-1-antitrypsin are independent of each other in patients with lepromatous leprosy.
