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Transplant Proc ; 55(3): 715-717, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36931953

ABSTRACT

Aplastic anemia is potentially fatal, particularly if the disease does not respond to immunotherapy and progresses to severe pancytopenia. Allogeneic hematopoietic stem cell transplant from an HLA-matched sibling donor, the first-line treatment in patients younger than 40 years, is used as a curative treatment option in severe aplastic anemia. The availability of an identical twin donor is infrequent, and there is limited experience in this context. Additionally, the choices for a conditioning regimen for a syngeneic transplant to prevent engraftment failure and the necessity of graft-vs-host disease prophylaxis are controversial. Although long-term survival gradually increases after an allogeneic hematopoietic stem cell transplant, hypogonadism and infertility are the main problems that significantly affect patients' quality of life. We present a patient diagnosed with severe aplastic anemia who has had a healthy pregnancy immediately after a syngeneic transplant.


Subject(s)
Anemia, Aplastic , Graft vs Host Disease , Hematopoietic Stem Cell Transplantation , Humans , Pregnancy , Female , Anemia, Aplastic/surgery , Anemia, Aplastic/complications , Transplantation, Isogeneic/adverse effects , Transplantation, Homologous/adverse effects , Quality of Life , Hematopoietic Stem Cell Transplantation/adverse effects , Graft vs Host Disease/etiology , Transplantation Conditioning
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