ABSTRACT
Juvenile hyaline fibromatosis is a rare autosomal recessive disease of the connective tissue. We present the case of a 6-year-old normal mental developed boy with confluent pearly papules behind the ears and in the paranasal folds, firm nodules of the scalp, the back and metaphalangs, and severe gingival hypertrophy.
Subject(s)
Fibroma/diagnosis , Fibroma/therapy , Hyaline Membrane Disease/diagnosis , Hyaline Membrane Disease/therapy , Skin Neoplasms/diagnosis , Skin Neoplasms/therapy , Child , Diagnosis, Differential , Humans , Infant, Newborn , MaleABSTRACT
BACKGROUND: A work force based case-control study of lung cancer was performed in non-silicotic subjects exposed to crystalline silica to investigate the association between silica dust and lung cancer excluding the influence of silicosis. METHODS: Two hundred and forty seven patients with lung cancer and 795 control subjects were enrolled, all of whom had been employed in the German stone, quarrying, or ceramics industries. Smoking was used as a matching criterion. Exposure to silica was quantified by measurements, if available, or otherwise by industrial hygienists. Several indices (peak, average and cumulative exposure) were used to analyse the relationship between the level of exposure and risk of lung cancer as odds ratios (OR). RESULTS: The risk of lung cancer is associated with the year of and age at first exposure to silica, duration of exposure, and latency. All odds ratios were adjusted for these factors. Considering the peak exposure, the OR for workers exposed to high levels (>/=0.15 mg/m3 respirable silica dust which is the current occupational threshold value for Germany) compared with those exposed to low levels (<0.15 mg/m3) was 0.85 (95% CI 0.58 to 1. 25). For the time weighted average exposure the OR was 0.91 (95% CI 0.57 to 1.46). The OR for the cumulative exposure was 1.02 (95% CI 0. 67 to 1.55). No increase in risk was evident with increasing exposure. CONCLUSIONS: This study shows no association between exposure to crystalline silica and lung cancer. The exclusion of subjects with silicosis may have led to dilution with respect to the level of exposure and therefore reduced the power to detect a small risk. Alternatively, the risk of getting lung cancer may be restricted to subjects with silicosis and is not directly linked to silica dust.
Subject(s)
Dust/adverse effects , Lung Neoplasms/etiology , Occupational Diseases/etiology , Occupational Exposure/adverse effects , Silicon Dioxide/adverse effects , Adult , Aged , Aged, 80 and over , Case-Control Studies , Female , Humans , Male , Middle Aged , Odds Ratio , Risk Factors , Time FactorsSubject(s)
Family Health , Family , Health Education/methods , Life Style , Child, Preschool , Germany, East , Humans , InfantSubject(s)
Family Health , Family , Health Education/methods , Life Style , Child , Child, Preschool , Germany, East , Humans , Infant , Risk FactorsABSTRACT
PIP: Data on 686 families in the German Democratic Republic are examined in order to identify factors affecting family size. Key factors identified include parents' occupation, whether or not the mother works, and attitudes toward parenthood. (summary in ENG, RUS)^ieng
