ABSTRACT
The expression of p16 as a tumor suppressor protein was evaluated in a retrospective analysis of paraffin-embedded tissue specimens of leiomyosarcoma (LMS), leiomyoma (LM) and normal myometrium. In this study, we investigated by immunohistochemistry p16 expression in 15 LMSs, 15 LMs and ten normal myometrium. Strong expression of p16 was found in 12 of the 15 LMSs and in three cases weak expression; three LMs had focal and weak p16 staining but none of the normal myometrium. A statistically significant difference regarding the frequency of p16 protein expression was observed between LMS and LM (p: 0.0001). We concluded that the results of this study confirm the overexpression of p16 in LMS. Therefore, the present study suggests that p16 might be a useful immunohistochemical marker which could help in distinguishing uterine LMS from LM and its benign variants.
Subject(s)
Cyclin-Dependent Kinase Inhibitor p16/analysis , Leiomyoma/metabolism , Leiomyosarcoma/metabolism , Tumor Suppressor Proteins/analysis , Uterine Neoplasms/metabolism , Adult , Female , Humans , Immunohistochemistry , Middle Aged , Myometrium/chemistryABSTRACT
Angioleiomyoma is a rare benign neoplasm that originates from smooth muscle cells and contains thick-walled blood vessels. A 69-year-old woman had been complaining of progressive abdominal distention for the last five years. At the exploration, a tumoral mass that could not be differentiated as to whether it had its origin from the uterus or ovary was specified. The patient underwent total hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). On pathologic examination of the specimen, the tumor was diagnosed as an angioleiomyoma. Here, we present a case of giant-multiple uterine angioleiomyomas mimicking an ovarian neoplasm.
Subject(s)
Angiomyoma/diagnosis , Angiomyoma/pathology , Ovarian Neoplasms/diagnosis , Uterine Diseases/diagnosis , Uterine Diseases/pathology , Aged , Angiomyoma/surgery , Diagnosis, Differential , Female , Humans , Hysterectomy , Ovariectomy , Uterine Diseases/surgeryABSTRACT
We are presenting a prenatally diagnosed case with sirenomelia, vestigial tail and polydactyly. A 30-year-old woman at 16 weeks of gestation with dichorionic twins was admitted to the hospital. Prenatal ultrasound demonstrated fusion of the lower limbs in one member and normal femurs, tibias and fibulas, and normal vertebras in the second twin, suggesting the diagnosis of sirenomelia. The twins were delivered vaginally at 35 weeks after spontaneous onset of labor. The affected newborn died after 24 hours and postnatal examination revealed unseparated lower limbs with extreme retroversion, bilateral pes equinus, unilateral postaxial polydactyly, a vestigial tail on the sacral region, a large and wide penis and anal atresia. There is only one previous report of sirenomelia with vestigial tail in the literature. However, a large, wide penis and polydactyly have not been reported before in association with this anomaly.
Subject(s)
Abnormalities, Multiple/genetics , Diseases in Twins/genetics , Ectromelia/genetics , Polydactyly/genetics , Sacrum/abnormalities , Ultrasonography, Prenatal , Abnormalities, Multiple/diagnostic imaging , Adult , Anus, Imperforate/diagnostic imaging , Anus, Imperforate/genetics , Diseases in Twins/diagnostic imaging , Ectromelia/diagnostic imaging , Female , Humans , Male , Penis/abnormalities , Penis/diagnostic imaging , Polydactyly/diagnostic imaging , Pregnancy , Sacrum/diagnostic imagingSubject(s)
Androgen-Insensitivity Syndrome/genetics , Androgens/physiology , Adolescent , Adult , Cytogenetics , Gonads/anatomy & histology , Humans , Karyotyping , Leydig Cells , Male , PhenotypeABSTRACT
Megalourethra due to urethral coitus is a very rare phenomenon in women. Anatomy, pathology and clinic are discussed.
