ABSTRACT
OBJECTIVE: To investigate whether amnioreduction has any impact on emergency cervical cerclage outcome. MATERIALS AND METHODS: Data of women who underwent emergency cervical cerclage for advanced cervical dilatation and protruding membranes were analyzed retrospectively. RESULTS: During the study interval, a total of 56 women who were underwent amnioreduction (n=26) and who did not (n=30) were eligible for analysis of the study. Gestational age at cerclage, delivery, and prolongation of pregnancy interval were comparable between the groups (21.3 ±3.3 vs. 20.6 ±3.1 weeks; p = 0.44; 28.3 ±6.1 vs. 28.1 ±5.6 weeks; p = 0.74; 53.7± 46.1 vs. 47.3± 36.7 days; p = 0.56 respectively). Number of live birth rates and perinatal mortality rates were also not statistically significantly different between the groups (73.1% vs. 70.0%; p = 0.80; 15.4% vs. 13.3%; p = 0.83). CONCLUSIONS: Emergency cerclage yields live take home baby rates in more than half of the patients. The decision to perform amnioreduction should be based on suspicion of chorioamnionitis and patient's motivation to know exactly what is the risk of chorioamnionitis.
Subject(s)
Amniotic Fluid , Cerclage, Cervical/methods , Emergencies , Adult , Cervix Uteri/physiology , Female , Gestational Age , Humans , Labor, Obstetric/physiology , Pregnancy , Retrospective StudiesABSTRACT
OBJECTIVE: To evaluate the effect of domperidone use on corrected QT interval in premature infants. STUDY DESIGN: A prospective study of premature infants receiving domperidone was included in this study. A baseline electrocardiogram was obtained just before and 3, 7 and 14 days after initiation of domperidone. Corrected QT was considered prolonged if it exceeded the upper limit for age. RESULT: A total of 40 premature infants were enrolled in this study. The mean birth weight of 1109+/-332 g, mean gestational age of 28.8+/-2.4 years and mean age at the onset of domperidone were 32.8+/-2 days. No difference in corrected QT interval was observed between just before and 3, 7 and 14 days after the start of the treatment. Two infants had corrected QT interval prolongation without any clinical side effect that resolved spontaneously. CONCLUSION: Our experience suggests that domperidone administered cautiously in modest doses does not result in arrhythmias or conduction defects in premature infants statistically. Additional data are needed to give optimal advice regarding the safety of domperidone treatment in premature infants.
Subject(s)
Domperidone/pharmacology , Dopamine Antagonists/pharmacology , Electrocardiography/drug effects , Gastroesophageal Reflux/drug therapy , Infant, Premature, Diseases/drug therapy , Female , Gastroesophageal Reflux/physiopathology , Humans , Infant , Infant, Newborn , Infant, Premature , Infant, Premature, Diseases/physiopathology , Male , Observation , Prospective StudiesABSTRACT
Many diagnostic methods have been used to establish the diagnosis for a suspected H-type tracheoesophageal fistula (TEF). In case of a strong assumption of an H-type fistula, besides all standard diagnostic work-up tools a more aggressive combined approach is advisable. However, in a critically ill premature infant, conventional invasive investigations could not be performed as being potentially hazardous and not always easy to achieve. We describe the unique imaging features of an H-type TEF on magnetic resonance imaging (MRI). Our case demonstrates that MR images could be used for diagnosis, and localization of an H-type TEF could be detected safely and accurately in a sick preterm infant.
Subject(s)
Infant, Very Low Birth Weight , Magnetic Resonance Imaging/methods , Sepsis/diagnosis , Tracheoesophageal Fistula/pathology , Tracheoesophageal Fistula/surgery , Disease Progression , Fatal Outcome , Humans , Infant, Newborn , Infant, Premature , Male , Postoperative Complications/physiopathology , Sensitivity and Specificity , Sepsis/therapy , Tracheoesophageal Fistula/congenitalSubject(s)
Congenital Hypothyroidism , Infant Formula , Soy Milk , Humans , Infant , Research Design , Thyrotropin/metabolismABSTRACT
TPIT is a highly cell-restricted transcription factor that is required for the expression of the propiomelanocortin (POMC) gene and for terminal differentiation of the pituitary corticotroph lineage. Its exclusive expression in pituitary POMC-expressing cells has suggested that its mutation may cause isolated deficiency of pituitary ACTH. We present a neonate with the diagnosis of congenital early onset isolated ACTH deficiency (IAD) associated with a loss of POMC function as a result of a missense mutation in the TPIT gene. A 5 day-old male infant was admitted for hypoglycemia, limpness and conjugated hyperbilirubinemia. Laboratory investigations indicated low plasma cortisol concentration (0.1 microg/dl) accompanying a very low ACTH (<5 pg/ml) concentration. An increase in plasma cortisol concentration following stimulation with low dose exogenous ACTH was observed. On replacement therapy with hydrocortisone (15 mg/m2/day orally), cholestatic jaundice and hypoglycemia resolved and subsequent normal growth (weight, height and head circumference, 25th, 10th and 50th percentile, respectively) and development was achieved without recurrence of hypoglycemic episodes.
Subject(s)
Adrenocorticotropic Hormone/deficiency , Homeodomain Proteins/genetics , Mutation, Missense , Transcription Factors/genetics , Consanguinity , Female , Humans , Infant, Newborn , Male , Pedigree , T-Box Domain ProteinsABSTRACT
The effect of oral administration of desmopressin (DDAVP) solution was investigated in a very low birth weight premature infant with central diabetes insipidus that was associated with grade four germinal matrix hemorrhage. As an alternative to the nasal route, long-term successful management resulting in favorable growth and development during infancy was achieved using the oral route.
Subject(s)
Deamino Arginine Vasopressin/therapeutic use , Diabetes Insipidus/drug therapy , Hypoglycemic Agents/therapeutic use , Infant, Premature/physiology , Administration, Oral , Cerebral Hemorrhage, Traumatic/complications , Cerebral Hemorrhage, Traumatic/diagnostic imaging , Cerebral Ventriculography , Deamino Arginine Vasopressin/administration & dosage , Diabetes Insipidus/etiology , Humans , Hypoglycemic Agents/administration & dosage , Infant, Newborn , Infant, Very Low Birth Weight , Male , Tomography, X-Ray Computed , Weight Gain/drug effectsABSTRACT
We report a patient with clinical and cytogenetic findings consistent with DiGeorge-velocardiofacial syndrome and aplasia of the left lung. To the best of our knowledge, this is the first reported case of DiGeorge-velocardiofacial syndrome associated with unilateral lung aplasia. Gadolinium enhanced three-dimensional magnetic resonance angiography demonstrated associated right-sided aortic arch and left pulmonary artery agenesis.
Subject(s)
Abnormalities, Multiple/diagnosis , DiGeorge Syndrome/diagnosis , Lung/abnormalities , Aorta, Thoracic/abnormalities , Female , Humans , Infant, Newborn , Magnetic Resonance Angiography , Pulmonary Artery/abnormalitiesABSTRACT
This study was performed to determine the effectiveness of the Breese scoring system for the diagnosis of streptococcal pharyngitis with respect to different age groups. Two hundred and two children aged three years and younger (Group 1), and 514 children over three years old (Group 2) with complaints of acute pharyngitis were evaluated by Breese scoring and throat-swab cultures. In Group 1, no significant difference was detected in Breese scoring between subjects who had positive and negative culture for group A beta-hemolytic streptococci (GABHS). However, in Group 2 the mean value of the Breese scores was found to be higher in subjects who had positive GABHS. The diagnostic value of Breese scoring was examined for each group. Its sensitivity, and positive and negative predictive values were higher in Group 2 than in Group 1. In conclusion, Breese scoring was determined to be helpful in the diagnosis of streptococcal pharyngitis in children over three years of age.
