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1.
J Chem Phys ; 155(12): 124310, 2021 Sep 28.
Article in English | MEDLINE | ID: mdl-34598584

ABSTRACT

We theoretically investigate the possibility to use single-object spectroscopy to probe size variations of the bacteriochlorophyll aggregates inside chlorosomes. Chlorosomes are the light-harvesting organelles of green sulfur and non-sulfur bacteria. They are known to be the most efficient light-harvesting systems in nature. Key to this efficiency is the organization of bacteriochlorophyll molecules in large self-assembled aggregates that define the secondary structure inside the chlorosomes. Many studies have been reported to elucidate the morphology of these aggregates and the molecular packing inside them. It is widely believed that tubular aggregates play an important role. Because the size (radius and length) of these aggregates affects the optical and excitation energy transport properties, it is of interest to be able to probe these quantities inside chlorosomes. We show that a combination of single-chlorosome linear polarization resolved spectroscopy and single-chlorosome circular dichroism spectroscopy may be used to access the typical size of the tubular aggregates within a chlorosome and, thus, probe possible variations between individual chlorosomes that may result, for instance, from different stages in growth or different growth conditions.


Subject(s)
Bacteriochlorophylls/analysis , Bacteriochlorophylls/chemistry , Organelles/chemistry , Spectrum Analysis , Bacteria/chemistry , Bacteria/cytology
2.
Q J Exp Psychol B ; 53(2): 97-119, 2000 May.
Article in English | MEDLINE | ID: mdl-10881603

ABSTRACT

Presentation of unsignalled unconditioned stimuli (USs) interspersed among Pavlovian excitatory conditioning trials weakens conditioned responding to a target conditioned stimulus (CS; Rescorla, 1968). However, signalling these intertrial USs with another cue (a cover stimulus) has been shown to alleviate this degraded-contingency effect (e.g. Durlach, 1982, 1983). In contrast to signalling the intertrial USs, the present experiments examined the effect on the degraded-contingency effect of signalling the target CS-US pairings. Experiment 1, using parameters selected to avoid overshadowing, found that consistently presenting a cover stimulus immediately prior to the target CS-US pairings during degraded-contingency training alleviated the degraded-contingency effect. Experiment 2 examined the underlying mechanism responsible for this cover-stimulus effect through posttraining associative inflation of the cover stimulus or the context, and found that inflation of the cover stimulus attenuated responding to the target CS (i.e. empirical retrospective revaluation). The results are discussed in terms of various acquisition- and expression-focused models of acquired responding.


Subject(s)
Association Learning , Conditioning, Classical , Inhibition, Psychological , Animals , Cues , Female , Male , Models, Psychological , Perceptual Masking , Rats , Rats, Sprague-Dawley , Reinforcement, Psychology
3.
J Exp Psychol Anim Behav Process ; 24(3): 335-51, 1998 Jul.
Article in English | MEDLINE | ID: mdl-9679309

ABSTRACT

In 4 conditioned lick suppression experiments with rats, the combined effects of latent inhibition treatment followed by overshadowing treatment were assessed as a test of the comparator hypothesis's (R.R. Miller & L.D. Matzel, 1988) explanations of overshadowing and latent inhibition. Experiments 1 and 2 confirmed the prediction of the comparator hypothesis that combined latent inhibition and overshadowing treatments attenuate the response deficit produced by either treatment alone. Furthermore, consistent with the comparator hypothesis, posttraining changes in the associative status of the putative comparator stimulus altered responding to the target conditioned stimulus (Experiment 3), and switching contexts between latent inhibition and overshadowing treatments (Experiment 4) eliminated the interaction between the latent inhibition and overshadowing treatments.


Subject(s)
Inhibition, Psychological , Animals , Behavior, Animal , Conditioning, Psychological , Female , Male , Rats , Rats, Sprague-Dawley , Time Factors
4.
Behav Res Ther ; 36(1): 75-91, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9613018

ABSTRACT

The acquisition of anxiety disorders (e.g., phobias) is often thought to be mediated by classical conditioning processes (e.g., Wolpe, 1958, Psychotherapy by reciprocal inhibition Wolpe and Rowan, 1989, Behaviour Research and Therapy, 27, 583-585). Thus, the success of exposure therapy is possibly a consequence of extinction, and factors affecting extinction in Pavlovian conditioning are potentially relevant to clinicians who administer exposure therapy. The present experiments investigated the effects of conducting extinction in multiple contexts using rats as subjects in a conditioned suppression paradigm. In Experiment 1, subjects received conditioned stimulus (CS) and unconditioned stimulus (US) pairings in one context followed by extinction of that CS in one or three other contexts. When tested in an associatively neutral context (i.e., different from those of conditioning or extinction), rats that had received extinction in three contexts exhibited less responding to the CS than rats that had received extinction in one context. In Experiment 2, CS-US training occurred in either one or three contexts, followed by extinction of that CS in three other contexts. Testing in a neutral context revealed that rats conditioned in multiple contexts showed greater responding to the CS than rats trained in a single context. The results are discussed in the framework of memory retrieval, and the clinical implications are explored.


Subject(s)
Desensitization, Psychologic/methods , Generalization, Psychological , Phobic Disorders/therapy , Social Environment , Animals , Arousal , Conditioning, Classical , Extinction, Psychological , Female , Humans , Male , Phobic Disorders/psychology , Rats , Rats, Sprague-Dawley , Recurrence , Treatment Outcome
5.
J Exp Psychol Anim Behav Process ; 23(1): 15-30, 1997 Jan.
Article in English | MEDLINE | ID: mdl-9008860

ABSTRACT

Differences in processing representations of conditioned and unconditioned stimuli (CSs and USs) may result from either their temporal order in training (i.e., CSs precede USs) or the greater biological significance of USs. The CS- and US-preexposure effects were used to probe this question. These effects are similar except that context extinction between preexposure and training more readily attenuates the US- than the CS-preexposure effect. In Experiments 1, 2, and 5, context extinction following preexposure to the stimulus that later served as Event 1 in Event 1-->Event 2 pairings alleviated the response deficit due to Event 1 preexposure if Event 1 was biologically significant. In Experiments 3 and 4, context extinction alleviated the response deficit due to Event 2 preexposure if Event 2 was biologically significant. Thus, biological significance and not temporal order determines how a representation will be processed.


Subject(s)
Behavior, Animal/physiology , Conditioning, Psychological/physiology , Acoustic Stimulation , Animals , Female , Male , Rats , Rats, Sprague-Dawley
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