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Int J Pediatr Otorhinolaryngol ; 78(3): 551-3, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24491806

ABSTRACT

OBJECTIVE: To determine the level of advanced oxidation protein products (AOPPs) in children with chronic otitis media with effusion (COME), in an effort to elucidate the multifactorial etiology of this disease. METHODS: This study involved 25 COME patients and 30 healthy children (control group) recruited from the Ear, Nose and Throat (ENT) and Pediatric Departments, respectively, of the Haseki Research and Training Hospital. In the COME group, blood samples were collected before a middle ear operation, and middle ear fluid was sampled during the operation. Blood samples were also obtained from the control subjects. AOPP levels in the plasma and effusion fluid were measured by the spectrophotometric method. RESULTS: In the COME group, the mean AOPP levels in plasma and effusion fluid were 168.08 µmol/l and 412.75 µmol/l, respectively. In the control group, the mean plasma AOPP level was 141.54 µmol/l. The plasma AOPP levels did not significantly differ between the COME and control groups (p>0.05). In the COME group, however, the effusion fluid AOPP level (412.75 ± 204.54 µmol/l) was significantly higher than the plasma AOPP level (168.08 ± 68.45 µmol/l; p<0.01). CONCLUSION: We found that AOPP levels were elevated in the effusion fluid, but not in the plasma, of COME patients. Thus, COME was associated with protein oxidation abnormalities. Oxidative stress may play a role in the etiopathogenesis of COME, and AOPPs may be used as markers of oxidative stress; however, further studies are required to confirm these findings.


Subject(s)
Advanced Oxidation Protein Products/metabolism , Otitis Media with Effusion/diagnosis , Otitis Media with Effusion/metabolism , Advanced Oxidation Protein Products/analysis , Antioxidants/therapeutic use , Biomarkers/analysis , Biomarkers/metabolism , Case-Control Studies , Child , Child, Preschool , Chronic Disease , Female , Humans , Male , Otitis Media with Effusion/drug therapy , Oxidation-Reduction , Oxidative Stress/physiology , Prognosis , Reference Values , Risk Assessment , Sensitivity and Specificity , Severity of Illness Index
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