ABSTRACT
In this study, we aimed to investigate the effectiveness of etofenamate and compare it with methyl prednisolone in the experimental spinal cord trauma model. A total of 31 Wistar Albino rats weighed between 220 and 270 gr were used in this study. The rats were divided into three groups as the control; posttraumatic normal saline (NS), trauma + E; posttraumatic etofenamate; and trauma + methylprednisolone, posttraumatic methylprednisolone. All medications were given into the peritoneum. Six hours after trauma and drug administration, approximately 2 cm of cord segment in the area subjected to dorsal laminectomy was dissected from the dura spinal cord and removed. The samples were histopathologically examined. In this study, significant differences were found both between trauma + NS and trauma + methylprednisolone, and between trauma NS and trauma + etofenamate, and trauma + methylprednisolone and trauma + etofenamate groups according to the Ivan Damjanov criteria and in terms of petechial hemorrhage, diffuse bleeding, loss in the regulation of grey and white matters, edema, necrosis, and cystic degeneration findings. According to the Ivan Damjanov criteria, trauma + NS group was found as Grades 2-3, trauma + etofenamate group as Grade 1, and trauma + methylprednisolone as Grades 1-2. Neuroprotective effect of etofenamate was found to be stronger than that of methyl prednisolone in rats with induced posttraumatic spinal cord damage (Tab. 4, Ref. 24). Keywords: etofenamate, methylprednisolone, spinal trauma, rats.
Subject(s)
Anti-Inflammatory Agents , Methylprednisolone , Neuroprotective Agents , Spinal Cord Injuries , Animals , Anti-Inflammatory Agents/pharmacology , Disease Models, Animal , Methylprednisolone/pharmacology , Neuroprotective Agents/pharmacology , Rats , Rats, Wistar , Spinal Cord , Spinal Cord Injuries/drug therapyABSTRACT
BACKGROUND: Heat shock protein (60 kd HSP) has been implicated in the etiology of Behçet's disease, but its expression at sites of inflammation is unknown. OBJECTIVE: Our aim was to investigate local HSP 60 expression and to quantify T-cell receptor (TCR) gamma delta-positive cells, which are known to respond to HSP peptides. METHODS: Patients with active Behçet's disease (n = 21) and controls (n = 18) were included. Flow cytometric analysis was performed on peripheral blood to investigate TCR gamma delta-positive cell counts. Biopsies were performed on active skin lesions, and immunohistochemical analysis was performed by a streptavidin-biotin method using the monoclonal ML-30 antibody; HSP staining intensity and distribution were evaluated in a blinded fashion. Immunohistochemical studies were performed to quantify TCR gamma delta-positive cells at lesional sites. RESULTS: Mucocutaneous lesions of patients with Behçet's disease had statistically significantly increased expression of HSP 60/65. Peripheral blood TCR gamma delta-positive cell counts were similar in both groups. However, lesional skin of patients with Behçet's disease had significantly increased gamma delta-positive T-cell counts. CONCLUSION: Up-regulation of HSP expression was found at lesional skin sites in Behçet's disease. The increased number of TCR gamma delta-positive cells, which are known to respond to HSP peptides, may support the function of HSPs in the etiology of Behçet's disease. However, these findings may also be an epiphenomenon that needs to be further investigated.
Subject(s)
Behcet Syndrome/metabolism , Chaperonin 60/analysis , Skin/chemistry , Adult , Aged , Female , Flow Cytometry , Humans , Immunohistochemistry , Male , Middle Aged , Mucous Membrane/chemistry , Receptors, Antigen, T-Cell, gamma-delta/analysisSubject(s)
Hyperpigmentation/pathology , Prurigo/pathology , Adult , Female , Humans , Hyperpigmentation/complications , Prurigo/complicationsABSTRACT
The authors present 344 (230 females, 114 males) surgical cases of intracranial meningioma. A total of 370 interventions (344 primary procedures, 10 reexplorations for neurologic deterioration, 16 operations for recurrence) were made. Mean follow-up was 38 months. The overall evaluation revealed that 306 (88.95%) patients were completely normal or in a better condition than before operation. 18 (5.23%) were in a worse condition after operation and 20 (5.81%) died. Results suggested that complications and mortality were mostly related to localization and large volume; we also still have problems with aggressive and malignant meningiomas.
Subject(s)
Meningeal Neoplasms/surgery , Meningioma/surgery , Adult , Aged , Child , Female , Humans , Male , Meningeal Neoplasms/complications , Meningeal Neoplasms/diagnosis , Meningioma/complications , Meningioma/diagnosis , Middle Aged , Neoplasm Recurrence, Local/surgery , Neurologic Examination , ReoperationABSTRACT
The authors present a young male patient with two intracranial lesions, one in the left occipital lobe, the other in the left temporal lobe. These masses were totally removed and both proved to be alveolar hydatid cysts. Surgery for a large hepatic mass, diagnosed after the first craniotomy, was refused by the patient.
