ABSTRACT
In 1,491 autopsy cases with CNS tumors observed at the Pathological Institute of the Medical Academy of Erfurt in the period from 1953 to 1976 (54,946 autopsies) 72 cases (4.8%) with neurinomas were found. They comprise 67 solitary neurinomas, 1 bilateral acoustic neurinoma without other signs of neurofibromatosis, and 4 cases of neurofibromatosis with neurinomas of the CNS. Among the 68 cases with CNS neurinomas (neurofibromatoses excluded) 87% were acoustic neurinomas, 12% spinal tumors, and 1 case was located in the trigeminal nerve. In 60 (88%) of these 68 cases, the neurinoma was operated upon or clinically diagnosed, resp. The diameter of 18 (26%) neurinomas of the autopsy material was larger than 5 cm. Patients in the 6th decennium predominated in this series. The sex distribution revealed a preponderance of females over males (3:1). In 3 cases further CNS tumors (ependymoma, glioblastoma, meningioma) were found. Additionally, 3 cases had carcinomas of different localization (Table 5). Following tumors were seen in 9 cases of Morbus Recklinghausen with CNS involvement: 4 cases with multiple neurinomas, 3 meningiomas, 1 astrocytoma, 2 glioses and 1 angiomatous malformation (Table 6). Among 1,670 CNS tumors in biopsy material, 144 (8.6%) were neurinomas. 60% of them were located in the nervus acusticus, 40% spinally, mainly in the thoracic region. The 6th decennium was most affected, and females were more frequent than males (2:1) in our material. Nearly all CNS neurinomas were benign. Only 1 spinal tumors was classified as a malignant neurinoma. 2 of the 9 cases with Morbus Recklinghausen had malignant neurogenic tumors (neurofibrosarcomas).
Subject(s)
Central Nervous System Diseases/pathology , Neurilemmoma/pathology , Adolescent , Adult , Age Factors , Aged , Autopsy , Biopsy , Cranial Nerve Neoplasms/pathology , Female , Humans , Male , Middle Aged , Neurofibromatosis 1/pathology , Neuroma, Acoustic/pathology , Sex Factors , Spinal Cord Neoplasms/pathology , Trigeminal NerveSubject(s)
Meningeal Neoplasms/pathology , Meningioma/pathology , Adolescent , Adult , Age Factors , Aged , Autopsy , Biopsy , Child , Child, Preschool , Female , Germany, East , Humans , Infant , Male , Meningeal Neoplasms/epidemiology , Meninges/pathology , Meningioma/epidemiology , Middle Aged , Sex FactorsSubject(s)
Brain Neoplasms/pathology , Glioma/pathology , Spinal Cord Neoplasms/pathology , Age Factors , Autopsy , Basal Ganglia/pathology , Biopsy , Female , Frontal Lobe/pathology , Humans , Male , Middle Aged , Occipital Lobe/pathology , Parietal Lobe/pathology , Sex Factors , Temporal Lobe/pathologySubject(s)
Central Nervous System Diseases/pathology , Neoplasms, Nerve Tissue/pathology , Adolescent , Adult , Aged , Autopsy , Biopsy , Brain/pathology , Cerebellar Neoplasms/pathology , Child , Child, Preschool , Female , Hemangioma/pathology , Hemangiosarcoma/pathology , Humans , Infant , Male , Medulla Oblongata/pathology , Middle Aged , Pons/pathologySubject(s)
Astrocytoma/pathology , Brain Neoplasms/pathology , Meningeal Neoplasms/pathology , Spinal Cord Neoplasms/pathology , Adolescent , Adult , Age Factors , Aged , Astrocytoma/epidemiology , Autopsy , Biopsy , Brain Neoplasms/epidemiology , Child , Child, Preschool , Female , Germany, East , Humans , Male , Middle Aged , Sex FactorsABSTRACT
The autopsy reports of the Pathological Institute Erfurt of the period from 1.1.1951 until 31.12.1969 were scored for cases of coronary atherosclerosis and myocardial infarction and analysed concerning frequency and distribution of age and sex, resp. In 89.05 per cent (2131 cases) of all myocardial infarctions a coronary sclerosis was present. Males suffered significantly more frequent from these forms of ischaemic heart disease. During the period of nineteen years a significant increase of the coronary atherosclerosis in combination with a myocardial infarction was observed. This is due to the more frequent occurrence of severe forms. The increase of the frequency of the myocardial infarctions and of the weak and moderately coronary sclerosis particularly concerns the younger age groups. Callous infarcts were more frequent than fresh and relapsing ones.
Subject(s)
Coronary Disease/pathology , Myocardial Infarction/pathology , Adolescent , Adult , Age Factors , Aged , Autopsy , Coronary Disease/complications , Female , Germany, East , Humans , Male , Middle Aged , Myocardial Infarction/complications , Sex FactorsABSTRACT
The autopsy reports of the Pathological Institute Erfurt of the period from 1.1.1951 until 31.12.1969 were scored for cases of myocardial infarction and coronary thrombosis. Among 2,393 morphologically analysed myocardial infarctions 454 coronary thromboses (18.97 per cent) were found. Males were significantly more affected than females. Fresh infarcts showed significantly more thromboses than callous infarcts. We found fresh and occluding vessel thromboses more frequently in fresh infarctions. The analysis of age distribution yielded an increase of the rate of thrombosis in cases with myocardial infarction. On the other hand, the frequency of infarctions in cases with a coronary thrombosis was decreasing. It is suggested that the risk for infarctions is larger in younger people with coronary thrombosis than in older ones. No infarctions were detected in 165 cases of thrombosis. Preferably this group includes those cases in which the patients deceased within 6 to 8 hours and, therefore, the infarction was not morphologically detectable.
Subject(s)
Coronary Disease/epidemiology , Myocardial Infarction/epidemiology , Adult , Age Factors , Aged , Autopsy , Cicatrix , Female , Germany, East , Humans , Male , Middle Aged , Sex FactorsSubject(s)
Central Nervous System Diseases/epidemiology , Neoplasms/epidemiology , Adolescent , Adult , Age Factors , Aged , Autopsy , Biopsy , Brain Neoplasms/epidemiology , Child , Child, Preschool , Female , Germany, East , Humans , Infant , Male , Meningeal Neoplasms/epidemiology , Middle Aged , Peripheral Nervous System Neoplasms/epidemiology , Sex Factors , Spinal Cord Neoplasms/epidemiologyABSTRACT
2393 cases of myocardial infarctions autopsied during the period from 1.1. 1951 until 31. 12. 1969 in our Institute were scored for aneurysm and rupture of the cardiac wall as well as for partietal thrombosis and endocardial fibrosis, and analysed concerning frequency and distribution of sex. Aneurysm of the ventricle walls was present in 23.94 per cent of myocardial infarctions. Most of the aneurysms were found in the posterior wall of the left ventricle. Callous infarctions showed more aneurysms than fresh myocardial lesions. A rupture was present in 31.82 per cent of acute aneurysms and in 4.53 per cent of old aneurysms. Parietal thromboses we found in 13.92 per cent of all infarctions. In 14.21 per cent of all myocardial infarctions endocardial fibroses were present. Parietal thromboses and endocardial fibroses were significantly most frequent in infarctions of the right ventricle.
Subject(s)
Coronary Disease/pathology , Myocardial Infarction/pathology , Acute Disease , Autopsy , Chronic Disease , Coronary Disease/complications , Female , Heart Aneurysm/complications , Humans , Male , Myocardial Infarction/complications , Rupture , Sex FactorsABSTRACT
The post-mortem material of the Erfurt Pathological Institute covering the period from 1953 to 1975 included 1376 primary tumours of the central nervous system, which corresponds to 2.6 per cent of all autopsies and 9.6 per cent of the autospies for malignant tumours. Thus, tumours of the central nervous system show the same frequency as leukoses and lymphomas and tumours of the female genitals and range before the tumours of the colon. The age distribution confirms well known conditions, but shows as apecu liarity that in infancy cerebral tumours occur just as frequently as in childhood and that the frequency of the occurrence of meningiomas before and after the 60th year of life is practically the same; but after that time they are clinically diagnosed in a distinctly less frequent number. Wrong clinical diagnoses were made in 23.5 per cent of the observations. Finally, it is pointed out that the intraoperative picture of the tumours may be misleading and only histological examinations will be helpful.
Subject(s)
Brain Neoplasms/epidemiology , Adolescent , Adult , Age Factors , Aged , Astrocytoma/epidemiology , Child , Child, Preschool , Ependymoma/epidemiology , Germany, East , Glioma/epidemiology , Humans , Infant , Infant, Newborn , Medulloblastoma/epidemiology , Meningioma/epidemiology , Middle Aged , Neurilemmoma/epidemiology , Pituitary Neoplasms/epidemiologyABSTRACT
The various classifications of tumours of the central nervous system employed at present are analysed. A generally accepted classification is still missing. In any case, one should avoid to place cerebral tumours outside the systems, or even to exclude them from the considerations of general oncology. A solution to the problem requires as far as possible a complete detection of all cerebral tumours by autopsy. In particular, patients who were not opperated can on furnish essential indications. Even histologically and clinically so important indications with regard to dignity and malignity cannot be obtained with absolute certainty. For the greater part of cerebral tumours, degrees of malignity ("grading") cannot be established with sufficient reliability. In the GDR tumour statistics, cerebral tumours are almost as frequent as leukoses or the so-called lymphomas.
Subject(s)
Brain Neoplasms/pathology , HumansABSTRACT
28978 cases of young (after the 14th year of age) and adult patients autopsied during the period from 1.1 1951 until 31. 12. 1969 in our Institute were scored for coronary thrombosis and analysed concerning frequency and distribution of age and sex, resp. In this material the evidence of morphological changes was proved by longitudinal dissection of the coronary vessels. We analysed the age of thrombi, the localization and the grading of coronary vessels occlusions. Coronary thrombi were found in 2,31 per cent of all autopsies (2,81 per cent in males,1,31 per cent in females). Coronary thromboses showed an increase during the observation period. These thrombi were found more frequently in younger patients. Most of the thrombi (62,20 per cent) were localized in the Arteria coronaria sinistra, 37,80 per cent we found in the Arteria coronaria dextra. Fresh thrombi (57,51 per cent) and those being in organization (42,49 per cent) were not significantly different. Obturating thromboses showed an increase. The numbers of non-obturating thromboses decreased during the observation period. Our findings correspond to similar results published in literature.
Subject(s)
Coronary Disease/epidemiology , Adolescent , Adult , Age Factors , Aged , Autopsy , Coronary Disease/pathology , Female , Germany, East , Humans , Male , Middle Aged , Sex Factors , Thrombosis/epidemiologyABSTRACT
The autopsy reports of the Pathological Institute Erfurt of the period from 1.1. 1951 untile 31.12. 1969 were scored for cases of coronary sclerosis and coronary thrombosis and analysed concerning frequency and distribution of age and sex, resp. In 3.97 per cent of all autopsies (4.93 per cent of men, 2.62 per cent of women) a coronary sclerosis was present in combination with a coronary thrombosis. Coronary thrombi appeared more frequent in severe coronary sclerosis (8.96%) than in weak or moderately severe coronary sclerosis (1.39%). Males suffered significantly more frequent from these forms of icaemic heart disease. Coronary thrombi were found more frequently in the left coronary artery (2.46%) than in the right coronary (1.51%). This difference was significant. Non obturating thromboses were more frequent than obturating ones and those being in organization were rarer than fresh thromboses. In all cases a decrease of the relative frequency of the coronary thrombosis with increasing age in men and women is detected.
Subject(s)
Coronary Disease/epidemiology , Adolescent , Adult , Age Factors , Aged , Arteriosclerosis/complications , Arteriosclerosis/epidemiology , Autopsy , Coronary Disease/pathology , Coronary Vessels , Female , Germany, East , Humans , Male , Middle Aged , Sex Factors , Thrombosis/complications , Thrombosis/epidemiologyABSTRACT
The autopsy reports of the Pathological Institute Erfurt of the period from 1. 1. 1951 until 31. 12. 1969 were scored for cases of myocardial infarction which were analyed concerning frequency and distribution of age, and sex, resp. The informations were transferred to punched cards and processed with electronic data equipment. In 8.26 per cent of all autopsies (males 10.32 per cent, femals 5.78 per cent) a myocardial infarction was present. During the period of nineteen years a significant increase of the myocardial infarctions was observed. Callous infarcts were more frequent than fresh and relapsing. Most of the infarcts were found in the posterior wall of the left ventricle.
Subject(s)
Myocardial Infarction/epidemiology , Adolescent , Adult , Age Factors , Aged , Autopsy , Coronary Disease/epidemiology , Coronary Vessels , Female , Germany, East , Humans , Male , Middle Aged , Myocardial Infarction/pathology , Sex Factors , Thrombosis/epidemiologyABSTRACT
The analysis is based on the catalogue of neoplasms notifiable in the German Democratic Republic (ICD-Code Nrs. 140-209, 210.2, 211.3, 211.9, 225, 226.2, 226.3, 253.2, 702, 757.2). At the Medical Academy of Erfurt 22155 autopsies (12212 males, 9943 females) of adults (15 years and upwards) were registered in the period from 1950 to 1966. Among them 322 leucoses (1,5% of autopsies and 4,3% of malignant tumours) were observed. The cases are distributed among 175 males (1,4% of males) and 147 females (1,5% of females). There is no sex difference in frequency. Age and sex distribution are presented for all leucoses and for chronic lymphatic leucosis, chronic myeloic leucosis and acute leucoses.
Subject(s)
Autopsy , Leukemia/epidemiology , Adolescent , Adult , Age Factors , Aged , Female , Germany, East , Humans , Leukemia, Lymphoid/epidemiology , Leukemia, Myeloid/epidemiology , Leukemia, Myeloid, Acute/epidemiology , Male , Middle Aged , Registries , Sex FactorsABSTRACT
The autopsy reports of the Pathological Institute Erfurt of the period from 1.1 1951 until 31.12. 1969 were scored for cases of coronary sclerosis which were analysed concerning frequency and distribution of age and sex, resp. In 52.26 percent of all autopsies (55.77 percent of men, 48.06 percent of women) a coronary sclerosis was present. Weak or moderately severe coronary sclerosis appeared more frequent (34.47 percent) than severe forms (17.80 percent of all autopsies). The difference in the relative frequency of coronary sclerosis between our material and the data of other authors we explain by subjective factors in the interpretation of the morphological changes of the coronary vessels. Males suffered significantly more frequent from all forms of coronary sclerosis. During the period of nineteen years a significant increase of the coronary sclerosis was observed. It is due to the more frequent occurrence of weak to moderately severe coronary sclerosis in both sexes, and of severe forms in men. The increase of the frequency of the coronary sclerosis particularly concerns the younger age groups.
